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Pregled bibliografske jedinice broj: 634836

Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives


Kos, Ivan; Jadrijević-Mladar Takač, Milena; Butula, Ivan; Biruš, Mladen; Maravić-Vlahoviček, Gordana; Dabelić, Sanja
Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives // Acta pharmaceutica, 63 (2013), 2; 174-190 doi:10.2478/acph-2013-0014 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 634836 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives

Autori
Kos, Ivan ; Jadrijević-Mladar Takač, Milena ; Butula, Ivan ; Biruš, Mladen ; Maravić-Vlahoviček, Gordana ; Dabelić, Sanja

Izvornik
Acta pharmaceutica (1330-0075) 63 (2013), 2; 174-190

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hydroxyurea derivatives; synthesis; antibacterial activity; cytotoxicity

Sažetak
Synthesis and biological evaluation of a series (N = 16) of cyclic and acyclic hydroxyurea derivatives, including benzotriazole-, isocyanuric acid- and biuret-containing compounds, are disclosed. 1-N-(benzyloxycarbamoyl)benzotriazole was used as a benzyloxyisocyanate donor, a useful intermediate in the preparation of substituted hydroxyurea. Antibacterial activities of synthesized hydroxyurea derivatives were tested on three E. coli strains, i.e., a strain susceptible to antibiotics, a strain resistant to macrolide antibiotics and a strain resistant to aminoglycoside antibiotics. Six compounds (three acyclic and three cyclic hydroxyureas) showed growth inhibition of the tested E. coli strains, with different specificity toward each strain. Results of the cytotoxic activity evaluation revealed that twelve out of sixteen test compounds were cytotoxic to human acute monocytic leukemia THP-1 and/or human acute T cell leukemia Jurkat cell line. 1-(N-hydroxycarbamoyl) benzotriazole (5) increased the metabolic activity of both cell lines. Two compounds, 1-(N-hydroxycarbamoyl) benzotriazole (5) and N, N’, N’’-trihydroxybiuret (15), were identified as potential NO donors.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Farmacija



POVEZANOST RADA


Projekti:
006-0061247-0009 - Kinetika i mehanizam katalitičkog antioksidacijskog djelovanja Mn-porfirina (Budimir, Ana, MZOS ) ( CroRIS)
006-0982913-1219 - Molekularne osnove djelovanja antibiotika i mehanizmi bakterijske rezistencije (Maravić Vlahoviček, Gordana, MZOS ) ( CroRIS)
006-0982929-2940 - Modeliranje molekula i materijala metodama matematičke i računarske kemije (Jadrijević-Mladar Takač, Milena, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb

Citiraj ovu publikaciju:

Kos, Ivan; Jadrijević-Mladar Takač, Milena; Butula, Ivan; Biruš, Mladen; Maravić-Vlahoviček, Gordana; Dabelić, Sanja
Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives // Acta pharmaceutica, 63 (2013), 2; 174-190 doi:10.2478/acph-2013-0014 (međunarodna recenzija, članak, znanstveni)
Kos, I., Jadrijević-Mladar Takač, M., Butula, I., Biruš, M., Maravić-Vlahoviček, G. & Dabelić, S. (2013) Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives. Acta pharmaceutica, 63 (2), 174-190 doi:10.2478/acph-2013-0014.
@article{article, author = {Kos, Ivan and Jadrijevi\'{c}-Mladar Taka\v{c}, Milena and Butula, Ivan and Biru\v{s}, Mladen and Maravi\'{c}-Vlahovi\v{c}ek, Gordana and Dabeli\'{c}, Sanja}, year = {2013}, pages = {174-190}, DOI = {10.2478/acph-2013-0014}, keywords = {hydroxyurea derivatives, synthesis, antibacterial activity, cytotoxicity}, journal = {Acta pharmaceutica}, doi = {10.2478/acph-2013-0014}, volume = {63}, number = {2}, issn = {1330-0075}, title = {Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives}, keyword = {hydroxyurea derivatives, synthesis, antibacterial activity, cytotoxicity} }
@article{article, author = {Kos, Ivan and Jadrijevi\'{c}-Mladar Taka\v{c}, Milena and Butula, Ivan and Biru\v{s}, Mladen and Maravi\'{c}-Vlahovi\v{c}ek, Gordana and Dabeli\'{c}, Sanja}, year = {2013}, pages = {174-190}, DOI = {10.2478/acph-2013-0014}, keywords = {hydroxyurea derivatives, synthesis, antibacterial activity, cytotoxicity}, journal = {Acta pharmaceutica}, doi = {10.2478/acph-2013-0014}, volume = {63}, number = {2}, issn = {1330-0075}, title = {Synthesis, antibacterial and cytotoxic activity evaluation of hydroxyurea derivatives}, keyword = {hydroxyurea derivatives, synthesis, antibacterial activity, cytotoxicity} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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