Naslov
Is Anti-Mullerian hormone (AMH) significantly related with hyperandrogenemia or insulin resistance in women with PCOS

Autori
Kralik Oguic, Saša ; Pavicic Baldani, Dinka ; Skrgatic, LAna ; Simunic, Velimir ; Vrcic, Hrvoje ; Rogic, Dunja ; Juras, Josip ; Šprem Goldštajn, Marina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 29th Annual Meeting of the European Society of Human Reproduction and Embryology, London, United Kingdom, 7–10 July 2013 / - , 2013, I340-i341

Skup
29th Annual Meeting of the European Society of Human Reproduction and Embryology, London, United Kingdom, 7–10 July 2013

Mjesto i datum
London, Ujedinjeno Kraljevstvo, 07.07.2013. - 10.07.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
PCOS; AMH

Sažetak
Study question Concentrations of AMH, androgens and insulin are elevated in women with PCOS. The question is if there is a correlation between levels of AMH and androgens or between AMH and insulin resistance estimated by HOMA-IR (homeostasis model of assessment ? insulin resistance). Summary answer In women with PCOS we found a statistically significant positive correlation between levels of AMH and free and total testosterone and androstenedione. There is no such correlation in healthy women without PCOS. No statistically significant correlation was found between AMH and insulin and HOMA-IR in both groups investigated. What is known already It is well known that AMH, testosterone (total and free), androstenedione, DHEAS, insulin and HOMA-IR are elevated in women with PCOS. Some studies found positive correlation between levels of AMH and androgens, but some didn't. The same situation is with relationship between AMH and insulin resistance in women with PCOS ; Depending on age and body mass index (BMI), there are studies with conflicting results ; Study design, size, duration A prospective study was conducted from 2009 to 2012 to investigate levels and the relationship of AMH with androgens and AMH with insulin resistance in 198 women with PCOS diagnosed according to the Rotterdam criteria and 170 healthy women without PCOS aged from 18 to 35 years ; Participants/materials, setting, methods Venous blood was taken during early follicular phase and concentrations of AMH, total testosterone, androstenedione, DHEAS, sex hormone binding globulin (SHBG), insulin were measured by routine immunochemical methods and glucose enzymatically with hexokinase. Free testosterone and HOMA-IR were calculate ; Results were evaluated statistically using SPSS 17 (IBM, NY, USA) ; Main results and the role of chance A significant positive correlation of AMH was established with total testosterone Wider implications of the findings Our results are in agreement with other studies that confirm positive correlation between levels of AMH and degree of hyperandrogenemia in women with PCOS ; These findings support the belief that intraovarian hyperandrogenism may cause follicular arrest and follicle excess followed by increased intraovarian AMH level ; Based on the results of our study, free testosterone and androstenedione are the most influential factors for increased AMH levels in women with PCOS

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA