Naslov
SYNTHESIS AND BIOLOGICAL ACTIVITY OF BENZIMIDAZOLE AND BENZIMIDAZO[1, 2-a]QUINOLINE DERIVATIVES
(SINTEZA I BIOLOŠKA AKTIVNOST DERIVATA BENZIMIDAZOLA I BENZIMIDAZO[1, 2-a]KINOLINA)

Autori
Hranjec, Marijana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
XXIII. Hrvatski skup kemičara i kemijskih inženjera - Knjiga sažetaka / Hadžiev, Andrea ; Blažeković, Zdenko - Zagreb : Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2013, 25-25

ISBN
978-953-6894-50-5

Skup
XXIII. Hrvatski skup kemičara i kemijskih inženjera

Mjesto i datum
Osijek, Hrvatska, 21.04.2013. - 24.04.2013

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
benzimidazo[1; 2-a]kinolini; antiproliferativna aktivnost; interakcija s ct-DNA; fluorescentne probe; kemosenzori
(benzimidazo[1; 2-a]quinolines; antiproliferative activity; interaction with ct-DNA; fluorescent probes; chemosensors)

Sažetak
Benzimidazoles represent the major backbone of numerous of synthetic medicinal and biochemical agents possessing different chemical and pharmacological features which impart them diverse biological properties. Recently, as a part of our continues scientific research in the field of potential, biologically active benzimidazoles, we have reported on the synthesis and biological activity of several groups of 2-styryl substituted benzimidazoles and benzimidazo[1, 2-a]quinolines and their heteroaromatic analogues, including positively charged amidino and amino substituted derivatives [1-2]. Biological studies confirmed the strong anticancer potential of this class of compounds while DNA/RNA binding studies revealed intercalation into ds DNA or RNA, especially of positively charged amidino substituted benzimidazo[1, 2-a]quinolines. Due to high fluorescence intensity and excellent spectroscopic characteristics, fused benzimidazoles offer also a potential application as fluorescent probes for detection of biological important molecules in biomedical diagnostics or as chemosensors that are capable of assaying cations in solution.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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