Naslov
CYP2D6 *3 and *4 polymorphism in cancer patients : a study on breast cancer and head and neck cancer

Autori
Štefanović, Mario ; Ivanišević, Ana-Maria ; Topić, Elizabeta ; Petrinović, Rajka ; Orešić, V. ; Turić, Marko ; Čurčić, Ivica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clin Chem Lab Med 1999 ; vol 37 : Abstracts volume, Special supplement / Siest, Gerard - Milano : Walter de Gruyter, 1999

Skup
IFCC-World Lab, 17th International and 13th European congress of Clinical Chemistry and Laboratory Medicine

Mjesto i datum
Firenca, Italija, 06.06.1999. - 11.06.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
CYP2D6 polymorphism; cancer

Sažetak
We investigated the association between the most common Cytochrome P450 CYP2D6 null alleles (CYP2D6*3 and CYP2D6*4) in two different tumor types: breast cancer (BC) and head and neck cancer (HNC). Genotyping was performed in 53 controls, 39 HNC, and 53 BC female patients by PCR-SSCP on whole blood DNA. Study results showed allelic frequencies for *3 and *4 alleles in controls to be 0.9% and 17%, respectively ; among them 1.9% *3 and 29.5% *4 heterozygotes, and 2.3% *4 homozygotes. *3 homozygote was not identified among controls. In HNC patients, allelic frequencies for *3 and *4 alleles were 1.3% and 21.9%, respectively ; out of which 2.6% and 43.8% were heterozygotes for *3 and *4 allele, respectively. We observed no homozygotes. Among BC patients, no *3 allele was found, whereas the frequency of *4 allele was 20.7%. There were 26.8% of heterozygotes and 7.3% of homozygotes for *4 allele. The difference in *4 genotypes comparing the patients to controls was: p=0.05(Chi) for HNC patients and p=0.22(Chi) for BC patients. To confirm our findings suggesting that CYP2D6*4 allele could be a contributory factor for the development of different tumors, further study on larger groups is needed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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