Pregled bibliografske jedinice broj: 626931
Structure of novel mannoconjugates with heterocyclic oximes and their interaction with acetylcholinesterase
Structure of novel mannoconjugates with heterocyclic oximes and their interaction with acetylcholinesterase // 13th Medical Chemical Defence Conference 2011 : Current Status of Terapeutic Approaches to Nerve Agent Poisoning
München, 2011. str. 47-47 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 626931 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Structure of novel mannoconjugates with
heterocyclic oximes and their interaction with
acetylcholinesterase
Autori
Primožič, Ines ; Baumann, Krešimir ; Tomić- Pisarović, Srđanka
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
13th Medical Chemical Defence Conference 2011 : Current Status of Terapeutic Approaches to Nerve Agent Poisoning
/ - München, 2011, 47-47
Skup
13th Medical Chemical Defence Conference 2011
Mjesto i datum
München, Njemačka, 13.04.2011. - 14.04.2011
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
antidotes ; mannoconjugates ; oximes ; AChE
Sažetak
In the attempt to improve the quality of antidotes against organophosphorus poisoning, heterocyclic oxime reactivators of inhibited AChE were linked to the sugar moiety. It was found that the attachement of a glucose to the oxime derivative increases the bioavailability of the antidote because they can mor easily cross blood-brain barrier and the antidote is retained longer in the blood circulation. Moreover, sugar analogs are in principle less toxic than the non-sugar analogs.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
MZOS-119-1191344-3121 - Sinteze i enzimske transformacije biološki aktivnih spojeva (Tomić-Pisarović, Srđanka, MZOS ) ( CroRIS)
Ustanove:
Prirodoslovno-matematički fakultet, Zagreb
