Naslov
Paraoxonase genotype distribution in cardiovascular dieseases

Autori
Topić, Elizabeta ; Ivanišević, Ana-Maria ; Štefanović, Mario ; Nikolić, Vjeran ; Petrač, Dubravko ; Čubrilo-Turek, Mirjana ; Demarin, Vida ; Žuntar, Irena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Genes candidats de risque cardio-vasculaire et implications therapeutiques / - Nancy, 1999

Skup
2eme mini-colloque international de Biologie Prospective:Genes candidats de risque cardio-vasculaire et implications therapeutiques

Mjesto i datum
Nancy, Francuska, 22.03.1999. - 23.03.1999

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
paraoxonase; CVD

Sažetak
Paraoxonase (PON1) genetic polymorphism at codon 192 (glutamine to arginine substitution, genotypes A and B, respectively) has been shown to affect the risk of CVD. The aim of this study was to genotype 44 controls and 100 CVD patients with different diagnosis (coronary artery disease (CAD), myocardial infarction (MI), hypertension and carotid stenosis (CS)) by PCR-RFLP using Alw1 restriction enzyme. Study results showed that out of 44 controls 18/44 (40.9%) were A and 1/44 (2.3%) B homozygotes and 25/44 (56.8%) heterozygotes. Among 31 CAD patients 9/31 (29.0%) were A and 5/31 (16.1%) B homozygotes and 17/31 (54.8%) heterozygotes. In 27 MI patients 8/27 (29.6%) were A and 4/27 (14.8%) B homozygotes and 15/27 (55.6%) heterozygotes. Out of 16 hypertension patients 6/16 (37.5%) were A and 3/16 (18.8%) B homozygotes and 7/16 (43.8%) heterozygotes. Among 26 CS patients 15/26 (57.7%) were A and 2/26 (7.7%) B homozygotes and 9/26 (34.6%) heterozygotes. Genotypes between controls and patients differed significantly (Chi-square test; P=0.002, 0.003, <0.001 and 0.003; for CAD, MI, Hypertension and CS patients, respectively). Allelic frequencies did not differ significantly between controls and patients. Our findings indicate the association between the codon 192 polymorphism of PON1 gene and cardiovascular diseases.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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