Naslov
Loss of heterozygosity of the APC gene in a case of vestibular schwannoma assessed by two intragenetic markers

Autori
Pećina-Šlaus, Nives

Izvornik
Acta clinica Croatica (0353-9466) 51 (2012), 4; 643-647

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Schwannoma; APC gene; Loss of heterozygosity; Neurinoma

Sažetak
Schwannomas are benign encapsulated tumors of Schwann cells, the main peripheral glia cells. The majority of schwannomas arise spontaneously and represent 8% of intracranial tumors. Those that strike cerebellopontine angle are in 90% of cases schwannomas. I would like to bring into your attention our finding on loss of heterozygosity of APC (adenomatous polyposis coli) gene in a case of cranial schwannoma from a Croatian patient. The observed change of the APC gene was investigated by the use of two intragenetic markers. In the light of novel findings on merlin’s connection to the wnt signaling reported in the literature, the finding of gross deletion in a case of cranial vestibular schwannoma from a female patient is a relevant genetic event.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA