Naslov
Rernal metastasis from pulmonary adenoid cystic carcinoma

Autori
Labinac-Peteh, Loredana ; Kučinar, Ilija ; Božac, F. ; Džombeta, Tihana ; Krušlin, Božo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
23th Ljudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 01.06.2012. - 02.06.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
renal metastasis

Sažetak
Adenoid cystic carcinoma (ACC) is a malignant epithelial neoplasm most commonly occurring in salivary glands. Its occurrence in the lungs is rare, accounting for less than 1% of all lung tumors. Patients frequently develop local recurrence with late metastases, probably because of the infiltrating margins. Metastases from pulmonary ACC to the kidney are extremely rare, with only four cases reported in the literature to date. Here, we report a case of solitary metastasis from pulmonary ACC to the kidney. A 49-year-old male presented with symptoms of obstructive nephropathy with elevated serum creatinine. Computed tomography scan showed an expansive process of the left kidney. Nephrectomy was performed. Grossly, the kidney contained a tumor measuring 7.2 cm in diameter, located in the pelvis, but deeply infiltrating the parenchyma. The tumor was soft, pale yellow on the cut surface. Histologically, it was composed of atypical epithelial cells forming solid nests and tubules surrounded by basement membrane-like material. Foci of perineural invasion and necrosis were seen. A larger branch of renal vein contained tumor thrombus. Medical history revealed right upper lung lobectomy due to a carcinoma three years before. The slides from the aforementioned lung carcinoma were reviewed. Owing to identical histologic appearance, the diagnosis of metastatic adenoid cystic carcinoma from the lung to the kidney was made. In conclusion, the biological behavior of ACC is characterized by multiple recurrences and late metastasis. This case emphasizes the need for long and close clinical monitoring of these patients.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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