Naslov
EPR study of radiation induced radicals in different polymorphic forms of trehalose

Autori
Šarić, Iva ; Jokić, Milan ; Rakvin, Boris ; Kveder, Marina ; Maltar-Strmečki, Nadica

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
The Joint International Symposium on EPR Dosimetry and Dating and the International Conference on Biological Dosimetry, Leiden, 24-28.03.2013, Abstracts / Firouz, Darroudi - Leiden, 2013, 189-189

Skup
EPRBioDose International Conference 2013 joint 9th International Symposium on EPR Dosimetry and Applications and 4th International Conference on Biodosimetry, Leiden, 24-28.03.2013

Mjesto i datum
Liblice, Češka Republika, 24.03.2013. - 28.03.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
trehalose; irradiation; spin concentration; EPR
(trehaloza; zračenje; koncentracija spinova; EPR)

Sažetak
Trehalose, a non-reducing disaccharide is a subject of common interest in many research areas such as biology, chemistry, food chemistry, pharmaceutics, bioscience etc. Trehalose like other disaccharides was intensively studied due to its bio-protection properties such as anhydrobiosis or cryoprotection, which refer to their ability to allow organisms to survive under extreme dehydration or freezing conditions 1. Although this mechanism is still not properly understood, many researchers believe that protection of the biomaterials and living organisms under extreme conditions is associated with properties of amorphous matrices, being inversely related to the degree of crystallization2. Consequently, the polymorphism of trehalose has been the subject of intense research in recent time. On the other hand, trehalose is suitable as a model system for investigation of the nature and reactions of radicals induced by direct radiation effects in the deoxyribose sugar of DNA 3. Furthermore, understanding the behavior of radiation-induced defects in trehalose in different polymorphic forms is important for radiation dosimetry purposes 4 and for the detection and characterization of irradiated final products in the pharmaceutical and food industry. The aim of this study was to investigate EPR response of radiation induced radicals in different polymorphic forms of trehalose. Number of free radicals, thermal stability and decay kinetics of EPR signals in γ-irradiated trehalose in different polymorphic forms were investigated using isothermal and isochronal annealing experiments.

Izvorni jezik
Engleski

Znanstvena područja
Fizika, Kemija

POVEZANOST RADA