Naslov
Piscine cytochromes P450 (CYP) and their response to antimicrobial drugs

Autori
Topić Popović, Natalija ; Sauerborn Klobučar, Roberta ; Strunjak-Perović, Ivančica ; Jadan, Margita ; Barišić, Josip ; Čož-Rakovac, Rozelinda

Izvornik
Aquaculture research (1355-557X) 46 (2015), 2; 257-271

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
cytochrome P450; CYP; fish; biotransformation; antimicrobial therapy

Sažetak
Most research on the P450 (CYP) system in teleosts has been done on environmental factors that influence their induction. Less is known about CYP metabolism of aquaculture antibiotics. This paper outlines the impact of aquaculture antimicrobials on the piscine CYP system, with particular regard to interactions with tetracyclines, fluorokinolones, sulfonamides, berberine and chloramphenicol, as paradigms for current, potential and discontinued piscine antimicrobial drugs. It gives an overview of literature reports and advances in the field of biological significance of the CYP in fish. Emphasis has been placed on highlighting the most significant isoforms for biotransformation of drugs, and their drug response mechanisms. The challenge is to elucidate the differences in responses of CYP enzymes in different species to antimicrobial treatment since they may have relevance for the use of antimicrobials in aquaculture, especially since drug interactions with the fish CYP may alter their distribution, metabolism, and elimination. They can impact the metabolism of other drugs metabolized by the same system with an effect on the physiology of fish administered these antimicrobials. Also, they can affect the persistence of residues and the length of the withdrawal period. For food animals such as farmed fish, this knowledge is a fundamental biomedical goal.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina, Poljoprivreda (agronomija), Biotehnologija

POVEZANOST RADA