Pregled bibliografske jedinice broj: 620937
Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands
Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands // Journal of Virology, 87 (2013), 6; 3592-3596 doi:10.1128/JVI.02657-12 (međunarodna recenzija, članak, znanstveni)
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Naslov
Viral inhibition of BAK promotes murine cytomegalovirus dissemination to salivary glands
Autori
Handke, W. ; Luig, C. ; Popović, Branka ; Krmpotić, Astrid ; Jonjić, Stipan ; Brune, W.
Izvornik
Journal of Virology (0022-538X) 87
(2013), 6;
3592-3596
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
cytomegalovirus; BAK; apoptosis
Sažetak
Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1−/− mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Krmpotić, Astrid, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE