Naslov
Influence of Active Dendrites on Firing Patterns in a Retinal Ganglion Cell Model

Autori
Guo, Tianruo ; Tsai, David ; Sovilj, Siniša ; Morley, John William ; Suaning, Gregg ; Lovell, Nigel ; Dokos, Socrates ;

Vrsta, podvrsta i kategorija rada
Radovi u zbornicima skupova, cjeloviti rad (in extenso), znanstveni

Izvornik
Engineering in Medicine and Biology Society (EMBC), 2013 Annual International Conference of the IEEE / Toshiyo Tamura, Nigel Lovell - : IEEE EMBC, 2013, 4557-4560

Skup
35th Annual International IEEE EMBS Conference of the IEEE Engineering in Medicine and Biology Society

Mjesto i datum
Osaka, Japan, 03.07.2013. - 07.07.2013

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Ionic modeling; Physiological systems; Parameter estimation

Sažetak
Active regional conductances and inhomogeneous distribution of membrane ionic channels in dendrites influence the integration of synaptic inputs in cortical neurons. How these properties shape the response properties of retinal ganglion cells (RGC) in the mammalian retina has remained largely unexplored. In this study, we used a morphologically-realistic RGC computational model to study how active dendritic properties contribute to neural behaviors. Our simulations suggest that the dendritic distribution of voltage-gated ionic channels strongly influences RGC firing patterns, indicating their important contribution to neuronal function.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Elektrotehnika, Računarstvo

POVEZANOST RADA