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Pregled bibliografske jedinice broj: 616730

Macrolactonolides: a novel class of anti- inflammatory compounds

Tomašković, Linda; Komac, Marijana; Makaruha Stegić, Oresta; Munić, Vesna; Ralić, Jovica; Stanić, Barbara; Banjanac, Mihailo; Marković, Stribor; Hrvačić, Boška; Čipčić Paljetak, Hana et al.
Macrolactonolides: a novel class of anti- inflammatory compounds // Bioorganic & medicinal chemistry, 21 (2013), 1; 321-332 doi:10.1016/j.bmc.2012.10.036 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 616730 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Macrolactonolides: a novel class of anti- inflammatory compounds

Autori
Tomašković, Linda ; Komac, Marijana ; Makaruha Stegić, Oresta ; Munić, Vesna ; Ralić, Jovica ; Stanić, Barbara ; Banjanac, Mihailo ; Marković, Stribor ; Hrvačić, Boška ; Čipčić Paljetak, Hana ; Padovan, Jasna ; Glojnarić, Ines ; Eraković Haber, Vesna ; Mesić, Milan ; Merćep, Mladen

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 21 (2013), 1; 321-332

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
concept; anti-inflammatory; glucocorticoid; macrolides

Sažetak
New concept in design of safe glucocorticoid therapy was introduced by conjugating potent glucocorticoid steroids with macrolides (macrolactonolides). These compounds were synthesized from various steroid 17β-carboxylic acids and 9a-N-(3-aminoalkyl) derivatives of 9- deokso- 9a-aza-9a-homoeritromicin A and 3- descladinosyl-9- deokso-9a-aza-9a-homoeritromicin A using stable alkyl chain. Combining property of macrolides to preferentially accumulate in immune cells, especially in phagocyte cells, with anti- inflammatory activity of classic steroids, we designed molecules which showed good anti- inflammatory activity in ovalbumin (OVA) induced asthma in rats. The synthesis, in vitro and in vivo anti- inflammatory activity of this novel class of compounds are described.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti



POVEZANOST RADA

Ustanove:
Fidelta d.o.o.

Profili:

Avatar Url Ines Glojnarić (autor)

Avatar Url Jovica Ralić (autor)

Avatar Url Vesna Munić (autor)

Avatar Url Hana Čipčić Paljetak (autor)

Avatar Url Linda Tomašković (autor)

Avatar Url Boška Hrvačić (autor)

Avatar Url Milan Mesić (autor)

Avatar Url Mihailo Banjanac (autor)

Avatar Url Vesna Munić Kos (autor)

Avatar Url Stribor Marković (autor)

Avatar Url Vesna Eraković Haber (autor)

Avatar Url Jasna Padovan (autor)

Avatar Url Mladen Merćep (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi www.sciencedirect.com ac.els-cdn.com dx.doi.org

Citiraj ovu publikaciju:

Tomašković, Linda; Komac, Marijana; Makaruha Stegić, Oresta; Munić, Vesna; Ralić, Jovica; Stanić, Barbara; Banjanac, Mihailo; Marković, Stribor; Hrvačić, Boška; Čipčić Paljetak, Hana et al.
Macrolactonolides: a novel class of anti- inflammatory compounds // Bioorganic & medicinal chemistry, 21 (2013), 1; 321-332 doi:10.1016/j.bmc.2012.10.036 (međunarodna recenzija, članak, znanstveni)
Tomašković, L., Komac, M., Makaruha Stegić, O., Munić, V., Ralić, J., Stanić, B., Banjanac, M., Marković, S., Hrvačić, B. & Čipčić Paljetak, H. (2013) Macrolactonolides: a novel class of anti- inflammatory compounds. Bioorganic & medicinal chemistry, 21 (1), 321-332 doi:10.1016/j.bmc.2012.10.036.
@article{article, author = {Toma\v{s}kovi\'{c}, Linda and Komac, Marijana and Makaruha Stegi\'{c}, Oresta and Muni\'{c}, Vesna and Rali\'{c}, Jovica and Stani\'{c}, Barbara and Banjanac, Mihailo and Markovi\'{c}, Stribor and Hrva\v{c}i\'{c}, Bo\v{s}ka and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Padovan, Jasna and Glojnari\'{c}, Ines and Erakovi\'{c} Haber, Vesna and Mesi\'{c}, Milan and Mer\'{c}ep, Mladen}, year = {2013}, pages = {321-332}, DOI = {10.1016/j.bmc.2012.10.036}, keywords = {concept, anti-inflammatory, glucocorticoid, macrolides}, journal = {Bioorganic and medicinal chemistry}, doi = {10.1016/j.bmc.2012.10.036}, volume = {21}, number = {1}, issn = {0968-0896}, title = {Macrolactonolides: a novel class of anti- inflammatory compounds}, keyword = {concept, anti-inflammatory, glucocorticoid, macrolides} }
@article{article, author = {Toma\v{s}kovi\'{c}, Linda and Komac, Marijana and Makaruha Stegi\'{c}, Oresta and Muni\'{c}, Vesna and Rali\'{c}, Jovica and Stani\'{c}, Barbara and Banjanac, Mihailo and Markovi\'{c}, Stribor and Hrva\v{c}i\'{c}, Bo\v{s}ka and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Padovan, Jasna and Glojnari\'{c}, Ines and Erakovi\'{c} Haber, Vesna and Mesi\'{c}, Milan and Mer\'{c}ep, Mladen}, year = {2013}, pages = {321-332}, DOI = {10.1016/j.bmc.2012.10.036}, keywords = {concept, anti-inflammatory, glucocorticoid, macrolides}, journal = {Bioorganic and medicinal chemistry}, doi = {10.1016/j.bmc.2012.10.036}, volume = {21}, number = {1}, issn = {0968-0896}, title = {Macrolactonolides: a novel class of anti- inflammatory compounds}, keyword = {concept, anti-inflammatory, glucocorticoid, macrolides} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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