Symptomatic Cardiac Metastases of Breast Cancer 27 Years after Mastectomy : A Case Report with Literature Review - Pathophysiology of Molecular Mechanisms and Metastatic Pathways, Clinical Aspects, Diagnostic Procedures and Treatment Modalities.

Katalinić, Darko; Štern-Padovan, Ranka; Ivanac, Irena; Alerić, Ivan; Tentor, Damir; Nikolac, Nora; Šantek, Fedor; Juretić, Antonio; Pleština, Stjepko

doi:10.1186/1477-7819-11-14

Pregled bibliografske jedinice broj: 615349

Symptomatic Cardiac Metastases of Breast Cancer 27 Years after Mastectomy : A Case Report with Literature Review - Pathophysiology of Molecular Mechanisms and Metastatic Pathways, Clinical Aspects, Diagnostic Procedures and Treatment Modalities.

Katalinić, Darko; Štern-Padovan, Ranka; Ivanac, Irena; Alerić, Ivan; Tentor, Damir; Nikolac, Nora; Šantek, Fedor; Juretić, Antonio; Pleština, Stjepko

Symptomatic Cardiac Metastases of Breast Cancer 27 Years after Mastectomy : A Case Report with Literature Review - Pathophysiology of Molecular Mechanisms and Metastatic Pathways, Clinical Aspects, Diagnostic Procedures and Treatment Modalities. // World Journal of Surgical Oncology, 11 (2013), 1; 14-1 doi:10.1186/1477-7819-11-14 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 615349 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Symptomatic Cardiac Metastases of Breast Cancer 27 Years after Mastectomy : A Case Report with Literature Review - Pathophysiology of Molecular Mechanisms and Metastatic Pathways, Clinical Aspects, Diagnostic Procedures and Treatment Modalities.

Autori
Katalinić, Darko ; Štern-Padovan, Ranka ; Ivanac, Irena ; Alerić, Ivan ; Tentor, Damir ; Nikolac, Nora ; Šantek, Fedor ; Juretić, Antonio ; Pleština, Stjepko

Izvornik
World Journal of Surgical Oncology (1477-7819) 11 (2013), 1; 14-1

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
heart metastases; breast cancer; pathophysiology; symptoms; treatment

Sažetak
Metastases to the heart and pericardium are rare but more common than primary cardiac tumours and are generally associated with a rather poor prognosis. Most cases are clinically silent and are undiagnosed in vivo until the autopsy. We present a female patient with a 27-year-old history of an operated primary breast cancer who was presented with dyspnoea, paroxysmal nocturnal dyspnoea and orthopnoea. The clinical signs and symptoms aroused suspicion of congestive heart failure. However, the cardiac metastases were detected during a routine cardiologic evaluation and confirmed with computed tomography imaging. Additionally, this paper outlines the pathophysiology of molecular and clinical mechanisms involved in the metastatic spreading, clinical presentation, diagnostic procedures and treatment of heart metastases. The present case demonstrates that a complete surgical resection and systemic chemotherapy may result in a favourable outcome for many years. However, a lifelong medical follow-up, with the purpose of a detection of metastases, is highly recommended. We strongly call the attention of clinicians to the fact that during the follow-up of all cancer patients, such heart failure may be a harbinger of the secondary heart involvement.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
108-1080058-0047 - Molekularni biljezi u solidnim tumorima - prediktivni i prognostički značaj (Pleština, Stjepko, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Klinički bolnički centar Zagreb

Profili:

Fedor Šantek (autor)