Pregled bibliografske jedinice broj: 615179
Innate immunity to cytomegalovirus in the murine model
Innate immunity to cytomegalovirus in the murine model // Cytomegaloviruses : from molecular pathogenesis to intervention / Reddehase, Matthias (ur.)., 2013. str. 192-214
CROSBI ID: 615179 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Innate immunity to cytomegalovirus in the murine model
Autori
Vidal, Silvia ; Krmpotić, Astrid ; Pyzik, Michal ; Jonjić, Stipan
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, ostalo
Knjiga
Cytomegaloviruses : from molecular pathogenesis to intervention
Urednik/ci
Reddehase, Matthias
Izdavač
Caister Academic Press
Godina
2013
Raspon stranica
192-214
ISBN
978-1-908230-18-8
Ključne riječi
innate immunity, cytomegalovirus, murine model
Sažetak
Cells of the innate immune system, including macrophages, DCs and NK cells play an important role in the control of viral infection before the induction of a specific immune response, of which generation they are also crucial. The infection of mice with MCMV as a model of HCMV infection has been particularly informative in elucidating the role of innate and adaptive immune response mechanisms during infection. NK cells are considered the most important effector cells in early CMV surveillance. An evolutionary struggle between NK cells and CMVs can be inferred from the existence of a broad range of viral mechanisms designed to compromise NK-cell function. This chapter describes major innate immune response mechanisms involved in control of MCMV, with an emphasis on NK-cell mediated viral detection as well as virally-encoded immune evasion mechanisms.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)
062-0621261-1268 - Uloga imunosubverzivnih citomegalovirusnih gena u latenciji (Krmpotić, Astrid, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka