Pregled bibliografske jedinice broj: 615176
Murine model of neonatal cytomegalovirus infection
Murine model of neonatal cytomegalovirus infection // Cytomegaloviruses : from molecular pathogenesis to intervention / Reddehase, Matthias (ur.)., 2013. str. 119-141
CROSBI ID: 615176 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Murine model of neonatal cytomegalovirus infection
Autori
Britt, William ; Cekinović, Đurđica ; Jonjić, Stipan
Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni
Knjiga
Cytomegaloviruses : from molecular pathogenesis to intervention
Urednik/ci
Reddehase, Matthias
Izdavač
Caister Academic Press
Godina
2013
Raspon stranica
119-141
ISBN
978-1-908230-18-8
Ključne riječi
murine cytomegalovirus, infection
Sažetak
Congenital HCMV infection of developing CNS is a major cause of long-term neuronal morbidity. Prevention of neurological damage due to CNS infection is considered as the primary goal of vaccine strategies and passively administered biologics. Due to species specificity of CMVs animal models have been developed in order to paradigmatically analyze the course of CMV infections. While different animal models provide good tools for studies of HCMV infections in the immunocompromised host, no single animal model completely recapitulates the pathogenesis of congenital HCMV infection. The murine model of perinatal MCMV infection in newborn mice has been proven as powerful tool to analyze the pathogenesis of congenital HCMV infection and mechanisms of the immune response which control CNS infection in the developing brain. This chapter describes a model of MCMV infection in neonatal mice that represents various aspects of HCMV infection in neonates, and thus, could be highly predictive for possible antiviral interventions in humans.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)
062-0621261-1269 - Perinatalni citomegalovirusni encefalitis (Pernjak-Pugel, Ester, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka