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Pregled bibliografske jedinice broj: 615176

Murine model of neonatal cytomegalovirus infection


Britt, William; Cekinović, Đurđica; Jonjić, Stipan
Murine model of neonatal cytomegalovirus infection // Cytomegaloviruses : from molecular pathogenesis to intervention / Reddehase, Matthias (ur.)., 2013. str. 119-141


CROSBI ID: 615176 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Murine model of neonatal cytomegalovirus infection

Autori
Britt, William ; Cekinović, Đurđica ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Cytomegaloviruses : from molecular pathogenesis to intervention

Urednik/ci
Reddehase, Matthias

Izdavač
Caister Academic Press

Godina
2013

Raspon stranica
119-141

ISBN
978-1-908230-18-8

Ključne riječi
murine cytomegalovirus, infection

Sažetak
Congenital HCMV infection of developing CNS is a major cause of long-term neuronal morbidity. Prevention of neurological damage due to CNS infection is considered as the primary goal of vaccine strategies and passively administered biologics. Due to species specificity of CMVs animal models have been developed in order to paradigmatically analyze the course of CMV infections. While different animal models provide good tools for studies of HCMV infections in the immunocompromised host, no single animal model completely recapitulates the pathogenesis of congenital HCMV infection. The murine model of perinatal MCMV infection in newborn mice has been proven as powerful tool to analyze the pathogenesis of congenital HCMV infection and mechanisms of the immune response which control CNS infection in the developing brain. This chapter describes a model of MCMV infection in neonatal mice that represents various aspects of HCMV infection in neonates, and thus, could be highly predictive for possible antiviral interventions in humans.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)
062-0621261-1269 - Perinatalni citomegalovirusni encefalitis (Pernjak-Pugel, Ester, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Citiraj ovu publikaciju:

Britt, William; Cekinović, Đurđica; Jonjić, Stipan
Murine model of neonatal cytomegalovirus infection // Cytomegaloviruses : from molecular pathogenesis to intervention / Reddehase, Matthias (ur.)., 2013. str. 119-141
Britt, W., Cekinović, Đ. & Jonjić, S. (2013) Murine model of neonatal cytomegalovirus infection. U: Reddehase, M. (ur.) Cytomegaloviruses : from molecular pathogenesis to intervention., Caister Academic Press, str. 119-141.
@inbook{inbook, author = {Britt, William and Cekinovi\'{c}, \DJur\djica and Jonji\'{c}, Stipan}, editor = {Reddehase, M.}, year = {2013}, pages = {119-141}, keywords = {murine cytomegalovirus, infection}, isbn = {978-1-908230-18-8}, title = {Murine model of neonatal cytomegalovirus infection}, keyword = {murine cytomegalovirus, infection}, publisher = {Caister Academic Press} }
@inbook{inbook, author = {Britt, William and Cekinovi\'{c}, \DJur\djica and Jonji\'{c}, Stipan}, editor = {Reddehase, M.}, year = {2013}, pages = {119-141}, keywords = {murine cytomegalovirus, infection}, isbn = {978-1-908230-18-8}, title = {Murine model of neonatal cytomegalovirus infection}, keyword = {murine cytomegalovirus, infection}, publisher = {Caister Academic Press} }




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