Pregled bibliografske jedinice broj: 612307
Inactivation of cholinesterases by silver and gold ions in vitro
Inactivation of cholinesterases by silver and gold ions in vitro // Central European Journal of Chemistry, 11 (2013), 6; 935-944 doi:10.2478/s11532-013-0225-4 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 612307 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Inactivation of cholinesterases by silver and gold ions in vitro
Autori
Vinković Vrček, Ivana ; Šinko, Goran
Izvornik
Central European Journal of Chemistry (1895-1066) 11
(2013), 6;
935-944
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
acetylcholinesterase; butyrylcholinesterase; silver; gold; Inhibition
Sažetak
The main goal of the present study was to investigate the effects of silver and gold ions on cholinesterases (ChEs) activity due to increasing application of these metals in a wide variety of nanomaterials. A chromogenic assay using the substrate o-nitrophenyl acetate/butyrate made it possible to conclude unmistakably that both metals inhibit ChEs. Addition of bovine serum albumin (BSA) indicates that binding of metal ions to albumin could serve to scavenge metals and consequently reduce their amount for reaction with ChEs. The effects of metal ions on ChE should be taken into consideration when using this enzyme as an environmental biomarker.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Javno zdravstvo i zdravstvena zaštita
POVEZANOST RADA
Projekti:
022-0222148-2135 - Izloženost metalima i njihovi učinci u graviditetu i postnatalnom razdoblju (Piasek, Martina, MZOS ) ( CroRIS)
022-0222148-2889 - Interakcije organofosfata, karbamata i određenih liganada s esterazama (Kovarik, Zrinka, MZOS ) ( CroRIS)
Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
