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Pregled bibliografske jedinice broj: 610454

Adjuvant thyroid remnant ablation in patients with differentiated thyroid carcinoma confined to the thyroid: a comparison of ablation success with different activities of radioiodine (I-131)


Prpić, Marin; Dabelić, Nina; Staničić, Josip; Jukić, Tomislav; Milošević, Milan; Kusić, Zvonko
Adjuvant thyroid remnant ablation in patients with differentiated thyroid carcinoma confined to the thyroid: a comparison of ablation success with different activities of radioiodine (I-131) // Annals of nuclear medicine, 26 (2012), 9; 744-751 doi:10.1007/s12149-012-0637-9 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 610454 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Adjuvant thyroid remnant ablation in patients with differentiated thyroid carcinoma confined to the thyroid: a comparison of ablation success with different activities of radioiodine (I-131)

Autori
Prpić, Marin ; Dabelić, Nina ; Staničić, Josip ; Jukić, Tomislav ; Milošević, Milan ; Kusić, Zvonko

Izvornik
Annals of nuclear medicine (0914-7187) 26 (2012), 9; 744-751

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
I-131; remnant ablation; thyroid cancer; predictive factors

Sažetak
Objective were to assess efficiency of various I-131 activities on thyroid remnant ablation in thyroid cancer patients. The significance of patients' characteristics, pathologic features and levels of Tg were analyzed. This study included 259 consecutive differentiated thyroid cancer patients, with disease confined to the thyroid, treated with I-131 after total thyroidectomy. Patients were divided into the three groups: 80 patients receiving low [1110-1850 MBq (30-50 mCi)], 121 intermediate [2775 MBq (75 mCi)] and 58 high [3700 MBq (100 mCi)] postoperative I-131 activities. Six to eight months after the application of radioiodine, measurements of TSH, Tg, anti-Tg antibodies (in hypothyroid state) together with ultrasound exam and whole-body scintigraphy were performed. The ablation was significantly more effective (after the first application) in patients receiving 100 mCi of I-131-89.7 % than in patients receiving lower activities (P = 0.016). There was no significant difference in ablation rate between the 30-50 mCi (77.5 %) and 75 mCi (70.2 %) groups. In the group receiving 30-50 mCi, patients with solitary tumors had significantly higher ablation rate (P = 0.038). In patients receiving 75 mCi ablation rates were higher among older patients (P = 0.005), with infiltration of the single lobe (P = 0.005), and with solitary tumor (P = 0.012). The rates of successful ablation after the second application of I-131 (after 12-16 months) amounted to 96, 97 and 96 % in the 30-50, 75 and 100 mCi groups, respectively. The activity of I-131 and age were independent factors for thyroid ablation failure after the first application of I-131 (model of binary logistic regression). The results of remnant ablation were satisfactory with all activities applied. Although after the first application of I-131 the activity of 100 mCi is significantly more effective in thyroid ablation than the administration of 30-50 mCi and 75 mCi, the ablation rates between all the three groups are similar (almost equal) after the second application. Thus, the activity to be administered may depend on patients' characteristics and a detailed consideration of the merits and demerits of each I-131 activity.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
134-1342428-2430 - Karcinogeneza u štitnjači i gušavost u Hrvatskoj (Kusić, Zvonko, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice"

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada doi link.springer.com

Citiraj ovu publikaciju:

Prpić, Marin; Dabelić, Nina; Staničić, Josip; Jukić, Tomislav; Milošević, Milan; Kusić, Zvonko
Adjuvant thyroid remnant ablation in patients with differentiated thyroid carcinoma confined to the thyroid: a comparison of ablation success with different activities of radioiodine (I-131) // Annals of nuclear medicine, 26 (2012), 9; 744-751 doi:10.1007/s12149-012-0637-9 (međunarodna recenzija, članak, znanstveni)
Prpić, M., Dabelić, N., Staničić, J., Jukić, T., Milošević, M. & Kusić, Z. (2012) Adjuvant thyroid remnant ablation in patients with differentiated thyroid carcinoma confined to the thyroid: a comparison of ablation success with different activities of radioiodine (I-131). Annals of nuclear medicine, 26 (9), 744-751 doi:10.1007/s12149-012-0637-9.
@article{article, author = {Prpi\'{c}, Marin and Dabeli\'{c}, Nina and Stani\v{c}i\'{c}, Josip and Juki\'{c}, Tomislav and Milo\v{s}evi\'{c}, Milan and Kusi\'{c}, Zvonko}, year = {2012}, pages = {744-751}, DOI = {10.1007/s12149-012-0637-9}, keywords = {I-131, remnant ablation, thyroid cancer, predictive factors}, journal = {Annals of nuclear medicine}, doi = {10.1007/s12149-012-0637-9}, volume = {26}, number = {9}, issn = {0914-7187}, title = {Adjuvant thyroid remnant ablation in patients with differentiated thyroid carcinoma confined to the thyroid: a comparison of ablation success with different activities of radioiodine (I-131)}, keyword = {I-131, remnant ablation, thyroid cancer, predictive factors} }
@article{article, author = {Prpi\'{c}, Marin and Dabeli\'{c}, Nina and Stani\v{c}i\'{c}, Josip and Juki\'{c}, Tomislav and Milo\v{s}evi\'{c}, Milan and Kusi\'{c}, Zvonko}, year = {2012}, pages = {744-751}, DOI = {10.1007/s12149-012-0637-9}, keywords = {I-131, remnant ablation, thyroid cancer, predictive factors}, journal = {Annals of nuclear medicine}, doi = {10.1007/s12149-012-0637-9}, volume = {26}, number = {9}, issn = {0914-7187}, title = {Adjuvant thyroid remnant ablation in patients with differentiated thyroid carcinoma confined to the thyroid: a comparison of ablation success with different activities of radioiodine (I-131)}, keyword = {I-131, remnant ablation, thyroid cancer, predictive factors} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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