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Pregled bibliografske jedinice broj: 609897

Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation

van Gisbergen, K.P.J.M.; Kragten, N.A.M.; Hertoghs, K.M.L.; Wensveen, Felix Martinus; Jonjić, Stipan; Hamann, J.; Nolte, M.A.; van Lier, R.A.V.
Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation // Nature immunology, 13 (2012), 9; 864-871 doi:10.1038/ni.2393 (međunarodna recenzija, članak, znanstveni)

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Naslov
Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation

Autori
Van Gisbergen, K.P.J.M. ; Kragten, N.A.M. ; Hertoghs, K.M.L. ; Wensveen, Felix Martinus ; Jonjić, Stipan ; Hamann, J. ; Nolte, M.A. ; van Lier, R.A.V.

Izvornik
Nature immunology (1529-2908) 13 (2012), 9; 864-871

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NK1(+) T-cellsS; natural-killer; Microbial onfection; cxtokine production; gene-expression; cutting edge; activation; interferon; aturation; lineage

Sažetak
The transcriptional repressor Blimp-1 mediates the terminal differentiation of many cell types, including T cells. Here we identified Hobit (Znf683) as a previously unrecognized homolog of Blimp-1 that was specifically expressed in mouse natural killer T cells (NKT cells). Through studies of Hobit-deficient mice, we found that Hobit was essential for the formation of mature thymic NKT cells. In the periphery, Hobit repressed the accumulation of interferon-g (IFN-g)-producing NK1.1lo NKT cells at steady state. After antigenic stimulation, Hobit repressed IFN-g expression, whereas after innate stimulation, Hobit induced granzyme B expression. Thus, reminiscent of the function of Blimp-1 in other lymphocytes, Hobit controlled the maintenance of quiescent, fully differentiated NKT cells and regulated their immediate effector functions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA

Projekti:
062-0621261-1263 - Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru (Jonjić, Stipan, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Profili:

Avatar Url Stipan Jonjić (autor)

Avatar Url Felix Martinus Wensveen (autor)

Poveznice na cjeloviti tekst rada:

doi www.nature.com

Citiraj ovu publikaciju:

van Gisbergen, K.P.J.M.; Kragten, N.A.M.; Hertoghs, K.M.L.; Wensveen, Felix Martinus; Jonjić, Stipan; Hamann, J.; Nolte, M.A.; van Lier, R.A.V.
Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation // Nature immunology, 13 (2012), 9; 864-871 doi:10.1038/ni.2393 (međunarodna recenzija, članak, znanstveni)
Van Gisbergen, K., Kragten, N., Hertoghs, K., Wensveen, F., Jonjić, S., Hamann, J., Nolte, M. & van Lier, R. (2012) Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation. Nature immunology, 13 (9), 864-871 doi:10.1038/ni.2393.
@article{article, author = {van Gisbergen, K.P.J.M. and Kragten, N.A.M. and Hertoghs, K.M.L. and Wensveen, Felix Martinus and Jonji\'{c}, Stipan and Hamann, J. and Nolte, M.A. and van Lier, R.A.V.}, year = {2012}, pages = {864-871}, DOI = {10.1038/ni.2393}, keywords = {NK1(+) T-cellsS, natural-killer, Microbial onfection, cxtokine production, gene-expression, cutting edge, activation, interferon, aturation, lineage}, journal = {Nature immunology}, doi = {10.1038/ni.2393}, volume = {13}, number = {9}, issn = {1529-2908}, title = {Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation}, keyword = {NK1(+) T-cellsS, natural-killer, Microbial onfection, cxtokine production, gene-expression, cutting edge, activation, interferon, aturation, lineage} }
@article{article, author = {van Gisbergen, K.P.J.M. and Kragten, N.A.M. and Hertoghs, K.M.L. and Wensveen, Felix Martinus and Jonji\'{c}, Stipan and Hamann, J. and Nolte, M.A. and van Lier, R.A.V.}, year = {2012}, pages = {864-871}, DOI = {10.1038/ni.2393}, keywords = {NK1(+) T-cellsS, natural-killer, Microbial onfection, cxtokine production, gene-expression, cutting edge, activation, interferon, aturation, lineage}, journal = {Nature immunology}, doi = {10.1038/ni.2393}, volume = {13}, number = {9}, issn = {1529-2908}, title = {Mouse Hobit is a homolog of the transcriptional repressor Blimp-1 that regulates NKT cell effector differentiation}, keyword = {NK1(+) T-cellsS, natural-killer, Microbial onfection, cxtokine production, gene-expression, cutting edge, activation, interferon, aturation, lineage} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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