Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction

Krstulović, Luka; Ismaili, Hamit; Bajić, Miroslav; Višnjevac, Aleksandar; Glavaš-Obrovac, Ljubica; Žinić, Biserka

doi:10.5562/cca2198

Pregled bibliografske jedinice broj: 609712

Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction

Krstulović, Luka; Ismaili, Hamit; Bajić, Miroslav; Višnjevac, Aleksandar; Glavaš-Obrovac, Ljubica; Žinić, Biserka

Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction // Croatica chemica acta, 85 (2012), 4; 525-534 doi:10.5562/cca2198 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 609712 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Synthesis of Novel Aliphatic N-sulfonylamidino Thymine Derivatives by Cu(I)-catalyzed Three-component Coupling Reaction

Autori
Krstulović, Luka ; Ismaili, Hamit ; Bajić, Miroslav ; Višnjevac, Aleksandar ; Glavaš-Obrovac, Ljubica ; Žinić, Biserka

Izvornik
Croatica chemica acta (0011-1643) 85 (2012), 4; 525-534

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
alkynes; azides; copper; nucleobases; N-sulfonylamidine

Sažetak
A series of new aliphatic N-sulfonylamidino thymine derivatives containing nucleobase, N-sulfonyl and amidine pharmacophores in the structure were synthesized by Cu(I)-catalyzed three component coupling of 1-propargyl thymine, benzenesulfonyl azides and amines or ammonium salts. Preliminary in vitro antitumor screening (human cervix adenocarcinoma -HeLa and leukemia cells - Jurkat)revealed promising activities of N, N-diethyl- (2) and N-4-cyanobenzyl- (6) derivatives of 4-acetamidobenzenesulfonyl amidine.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Temeljne medicinske znanosti

POVEZANOST RADA

Projekti:
053-0982914-2965 - Dizajn i sinteza bisamidina sa protutumorskim djelovanjem (Bajić, Miroslav, MZOS ) ( CroRIS)
098-0982914-2935 - Sinteza novih biološki aktivnih derivata nukleobaza i nukleotida (Žinić, Biserka, MZOS ) ( CroRIS)
219-0982914-2176 - Mehanizam bioloških učinaka novih malih molekula na stanice tumora čovjeka (Glavaš Obrovac, Ljubica, MZOS ) ( CroRIS)

Ustanove:
Veterinarski fakultet, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Osijek

Profili:

Aleksandar Višnjevac (autor)