Naslov
Prognostic significance of Matrix Metalloproteinases 2 and 9 in Endometrial Cancer

Autori
Puljiz, Mario ; Puljiz, Željko ; Vučemilo, Tiha ; Ramić, Snježana ; Knežević, Fabijan ; Čulo, Branimir ; Alvir, Ilija ; Tomica, Darko ; Danolić, Damir

Izvornik
Collegium antropologicum (0350-6134) 36 (2012), 4; 1367-1372

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Matrix metalloproteinase 2; Matrix metalloproteinase 9; Endometrial cancer; Recurrence

Sažetak
We investigated the prognostic significance of matrix metalloproteinases 2 (MMP 2) and 9 (MMP 9) in endometrial cancer (EC). The expression of MMP 2 and MMP 9 was analyzed immunohistochemically in 73 primary EC patients. In most cases, the gelatinases were predominantly localized to epithelial cell of tumor origin. In univariate analysis histological type, tumor grade, FIGO (1988) surgical stage and high stromal MMP 2 expression were identified as a significant determinant for EC recurrence, while epithelial MMP 2 expression and epithelial and stromal MMP 9 expression were not. Multivariate analysis revealed a subgroup of patient age ³63.6 years with endometrioid adenocarcinoma and papillary serous carcinoma, all FIGO (2009) stage I disease where strong staining of stromal MMP 2 increase risk of EC recurrence (p=0.037).

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA