Pretraga

Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 608470

Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height

Zhang, Ge; Karns, Rebekah; Sun, Guangyun; Indugula, Subba Rao; Cheng, Hong; Havas-Augustin, Dubravka; Novokmet, Natalija; Duraković, Zijad; Missoni, Sasa; Chakraborty, Ranajit et al.
Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height // PLoS One, 7 (2012), 12; 1-7 doi:10.1371/journal.pone.0047867 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 608470 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height

Autori
Zhang, Ge ; Karns, Rebekah ; Sun, Guangyun ; Indugula, Subba Rao ; Cheng, Hong ; Havas-Augustin, Dubravka ; Novokmet, Natalija ; Duraković, Zijad ; Missoni, Sasa ; Chakraborty, Ranajit ; Rudan, Pavao ; Deka, Ranjan

Izvornik
PLoS One (1932-6203) 7 (2012), 12; 1-7

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
heritability; allelic heterogeneity; human height

Sažetak
In a sample of 1 304 individuals collected from an island population of the Adriatic coast of Croatia, we assessed the extent of height variance explained by incorporating the effects of less significant height loci and multiple effective SNPs at the same loci. Approximately half of the 118 loci that achieved stringent genome-wide significance showed evidence of allelic heterogeneity. Additionally, including less significant loci and accounting for effects of allelic heterogeneity substantially improved the variance explained in height.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Etnologija i antropologija



POVEZANOST RADA

Projekti:
196-0342282-0291 - Promjene funkcija organa starenjem, radna sposobnost i biološka dob (Čoklo, Miran, MZOS ) ( CroRIS)
196-1962766-2751 - Populacijska struktura Hrvatske - antropogenetički pristup (Rudan, Pavao, MZOS ) ( CroRIS)

Ustanove:
Institut za antropologiju

Profili:

Avatar Url Dubravka Havaš Auguštin (autor)

Avatar Url Saša Missoni (autor)

Avatar Url Zijad Duraković (autor)

Avatar Url Tong Zhang (autor)

Avatar Url Natalija Novokmet (autor)

Avatar Url Pavao Rudan (autor)

Poveznice na cjeloviti tekst rada:

doi www.plosone.org

Citiraj ovu publikaciju:

Zhang, Ge; Karns, Rebekah; Sun, Guangyun; Indugula, Subba Rao; Cheng, Hong; Havas-Augustin, Dubravka; Novokmet, Natalija; Duraković, Zijad; Missoni, Sasa; Chakraborty, Ranajit et al.
Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height // PLoS One, 7 (2012), 12; 1-7 doi:10.1371/journal.pone.0047867 (međunarodna recenzija, članak, znanstveni)
Zhang, G., Karns, R., Sun, G., Indugula, S., Cheng, H., Havas-Augustin, D., Novokmet, N., Duraković, Z., Missoni, S. & Chakraborty, R. (2012) Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height. PLoS One, 7 (12), 1-7 doi:10.1371/journal.pone.0047867.
@article{article, author = {Zhang, Ge and Karns, Rebekah and Sun, Guangyun and Indugula, Subba Rao and Cheng, Hong and Havas-Augustin, Dubravka and Novokmet, Natalija and Durakovi\'{c}, Zijad and Missoni, Sasa and Chakraborty, Ranajit and Rudan, Pavao and Deka, Ranjan}, year = {2012}, pages = {1-7}, DOI = {10.1371/journal.pone.0047867}, keywords = {heritability, allelic heterogeneity, human height}, journal = {PLoS One}, doi = {10.1371/journal.pone.0047867}, volume = {7}, number = {12}, issn = {1932-6203}, title = {Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height}, keyword = {heritability, allelic heterogeneity, human height} }
@article{article, author = {Zhang, Ge and Karns, Rebekah and Sun, Guangyun and Indugula, Subba Rao and Cheng, Hong and Havas-Augustin, Dubravka and Novokmet, Natalija and Durakovi\'{c}, Zijad and Missoni, Sasa and Chakraborty, Ranajit and Rudan, Pavao and Deka, Ranjan}, year = {2012}, pages = {1-7}, DOI = {10.1371/journal.pone.0047867}, keywords = {heritability, allelic heterogeneity, human height}, journal = {PLoS One}, doi = {10.1371/journal.pone.0047867}, volume = {7}, number = {12}, issn = {1932-6203}, title = {Finding missing heritability in less significant loci and allelic heterogeneity: genetic variation in human height}, keyword = {heritability, allelic heterogeneity, human height} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

Uključenost u ostale bibliografske baze podataka::


  • MEDLINE

Citati:

    Altmetrijski pokazatelji:


    Podijeli:





    Contrast
    Increase Font
    Decrease Font
    Dyslexic Font
    CROSBI koristi kolačiće (cookies) kako bi poboljšao funkcionalnost stranice.