Naslov
Design of modular approaches to the total synthesis of neuroprotectin D1

Autori
Vazdar, Katarina ; Jahn, Ullrich

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
46. Pokroky v organické, bioorganické a farmaceutické chemii – „Liblice 2011“,

Mjesto i datum
Lázně Bělohrad, Češka Republika, 11.11.2011. - 13.11.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
neuroprotectins ; total synthesis

Sažetak
ω-3 Polyunsaturated fatty acids, besides having an essential role for the health of living organisms, undergo a large number of enzymatic transformations leading to compounds with potent anti-inflammatory and neuroprotective properties.1 Neuroprotectin D1 (NPD1) belongs to this family of lipid mediators and is found to be produced from docosahexaenoic acid (DHA) in retinal, fat and neural cells during oxidative stress induced diseases. NPD1 shows substantial neuroprotective, anti-inflammatory, regenerative and anti-apoptotic abilities.2, 3 Due to these properties NPD1 has become an interesting target molecule for the treatment of brain stroke and Alzheimer’s disease. Although two synthetic approaches were devised, 4, 5 new methods for very efficient, stereoselective and versatile syntheses of NPD1 and analogs are still needed. We present results of our efforts to design short and modular synthetic approaches to NPD1 and its analogs for various biological investigations.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA