Naslov
Towards the total synthesis of neuroprotectin D1

Autori
Vazdar, Katarina ; Jahn, Ullrich

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
XXIII Conference on Advances in Organic Synthesis (CAOS 2011)

Mjesto i datum
Hradec Králové, Češka Republika, 26.06.2011. - 30.06.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
neuroprotectins ; total synthesis

Sažetak
ω-3 Polyunsaturated fatty acids have for long been recognized for their essential role for the health of living organisms. It was demonstrated that these fatty acids undergo a large number of enzymatic transformations leading to compounds with potent anti-inflammatory and neuroprotective properties.1 Neuroprotectin D1 (NPD1) belongs to this family of still inadequately explored lipid-derived mediators. It is found to be produced from docosahexaenoic acid (DHA) in retinal and neural cells during oxidative stress induced diseases and shows substantial neuroprotective, anti-inflammatory, regenerative and anti-apoptotic abilities.2, 3 Due to these properties NPD1 has become an interesting target molecule for the treatment of brain stroke and Alzheimer’s disease and synthetic approaches were devised.4, 5 Nevertheless, new methods for very efficient, stereoselective and versatile syntheses of NPD1 and analogs are needed. We present results of our efforts to design a short and modular synthesis of NPD1 and analogs for various biological investigations.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA