Naslov
Prenatal and early postnatal development of modular organization in the human striatum

Autori
Sanja Darmopil, Nataša Jovanov-Milošević, Mario Vukšić, Ivica Kostović

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
SINAPSA Neuroscience Conference ’11, Central European FENS

Mjesto i datum
Ljubljana, Slovenija, 22.09.2011. - 25.09.2011

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
striatum; human development; CNS patterning; MAP-2; acetyl-cholinesterase

Sažetak
The mammalian neostriatum is organized as heterogeneous mosaic of various compartments that can be distinguished according their times of neurogenesis, anatomical connections and distribution of neuroactive substances. It is interesting that histochemical and cytoarchitectonical inhomogenties described in the developing brain are more pronounced than the ones described in the adult brain. However, exact relationship between fetal and adult modular organization of the striatum remains unclear especially in humans, where systematic study of development of striatal compartments is still missing. According to differences observed in prenatal and early postnatal human material stained with Nissl, acetyl-cholinesterase (AChE) histochemistry and several immunohistochemical markers we can distinguish four developmental periods. In a period from 10-14 postovulatory weeks (POW) first inhomogenities in the human fetal striatum are observed only by means of AChE. Cytoarchitectonical cell islands are first recognized on Nissl sections at 15 POW and are matching the islands of increased NeuN, tyrosine hydroxylase (TH) and synaptophysin immunoreactivity. 20-28 POW period represents a peak in fetal modular organization of the striatum that is characterized by appearance of cell free perimeters around islands. At 27-28 POW MAP-2 staining completely defines island compartment whereas synaptophysin immunostaining starts to shows uniform distribution. This pattern is present in developing human striatum until 3rd postnatal month when MAP-2, TH and AchE positive islands start to disappear in the putamen probably due to the increase in matrix staining.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA