Naslov
Regulatory network of T regulatory cells (Tregs) and NKT cells in environmental diseases

Autori
Bulog, Aleksandar ; Mićović, Vladimir ; Mrakovčić-Šutić, Ines ;

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
European Congress of Immunology-Glasgow 2012

Mjesto i datum
Glasgow, Ujedinjeno Kraljevstvo, 05.09.2012. - 08.09.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
environmental diseases; NKT cells; indoor and outdoor polution; Tregs;

Sažetak
Cytotoxic T lymphocytes and natural killer (NK) cells represent two major types of immune cytotoxic cells that have a crucial role in innate immunity. Urban air pollution represents a common and difficult problem in the majority of metropolises, which contain high levels of traffic congestion generating great amounts of genotoxic substances. Diesel exhaust particles act as adjuvant in the immune response and may lead to the enhancement of proinflammatory and proallergic response without exposure to allergen. The activities of diesel exhaust particles (DEPs) and their benzene extracts may cause the increasing respiratory mortality and morbidity. Since the lung inflammatory response to DEPs is compartmentalized, the importance of finding the suppressive substances, whose function will be to elucidate the DEPs effects, is fundamental. The objectives of this study were to examine the NK-mediated cytotoxicity against human NK-sensitive target, as well as the values of BTEX in urine in people from industrial area and those from rural fields. Methods of study: NK-mediated cytotoxicity of peripheral blood mononuclear cells was investigated against human NK-sensitive K-562 tumor cell line. BTEX were analyzed from urine by a HS-SPME method. The results were analyzed using the Sigma Plot for Windows, version 1.02. Statistical analyses were performed using a Student, s t-test one way analysis for comparison of means. All experiments have been approved by a local ethics committee. Results: all exposed individuals were demonstrated the significant decreased of NK-mediated cytotoxicity against human NK-sensitive target and increasing BTEX values. Conclusion: BTEX-analyze in urine and determination of NK-mediated cytotoxicity, as an important methods represent good markers in environmental monitoring, which contribute to the better protection of air pollutants and quicker diagnosis of environmental diseases. Acknowledgement: This work was supported by grants from the Croatian Ministry of Science (No 0621341-0308 and 0620096-0094).

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

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