Naslov
How to measure cognition in hematological-oncological patients?

Autori
Petranović, Duška ; Dintinjana Dobrila, Renata ; Valković, Toni ; Duletić Načinović, Antica ; Host, Ivan ; Rončević Gržeta, Ika ; Ružić, Klementina ; Petković, Marija ; Lovasić, Ingrid ; Ružić Pavlović, Ira

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Haematologica, 95 (suppl.2) / Cazzola, Mario - Pavia : Ferrata-Storti Foundation, 2010, 789-789

Skup
15th Congress of the European Hematology Association

Mjesto i datum
Barcelona, Španjolska, 10.06.2010. - 13.06.2010

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cognitive function; quality of life of malignant victims

Sažetak
Cognitive functions affect the quality of life of malignant disease victims. In research to date there has been a huge problem with objective measuring of cognitive abilities. Some very well-designed studies to date have not been conclusive and the authors themselves cited inadequate sensitivity of tests and equipment which were deficient in detecting minimal changes. The aim of research was to:1. assess to what extent malignant disease and anaemia are reflected on cognitive abilities of oncological-hemotological patients 2. define orientational norms for hematological-oncological patients, and 3. compare them with previously established norms for subjects with different educational levels and occupations using the state-of-the-art computerised equipment - a CRD instrument (Complex Reactiometer Drenovac). It is anticipated that the work will serve in designing future similar research. Subjects were chosen from a stratified sample of an adult patient population of both sexes who are under observation or being treated at Clinical Hospital Center, Rijeka, Croatia. A total of 400 patients divided in four commensurable groups (100 patients each) with or without malignant diseases and with or without anaemia were included in the study. The results of the psychological tests were analyzed through application of ANOVA statistical procedures. Through comparison of cognitive functions among groups, standard norms were made. Assignment indicators in the first testing (T1) and in the repeated testing (T2) after anaemia correction, checking differences in tests among the groups as well as testing the differences between the first and second testing, demonstrated that anaemia and malignant disease are significantly connected with loss of cognitive abilities. In all assignment indicators of cognitive tests, Group 1 (with malignant disease and anemia) demonstrated the worst results in comparison with all other groups (P<0.001). After correction of anaemia, cognition improves but does not reach the result of the other groups. In Group 1 after treatment of anaemia, there was a significant restoration of cognitive functions (P=0.001) in all tests except for tests CRD21 (visual orientation) and CRD 341 (memorising). Readings for cognitive functions of all tests were compared with previously defined standards in various populations of people which allowed us to define a normative for oncological haematological patients. It was concluded that anaemia and malignant disease significantly affect cognition, where they have an additive effect. With anaemia treatment, cognitive abilities are remedied but they never reach the level of anaemia-free patients or general population. Norms for oncological-hematological patients were compared with previously established norms for subjects of different educational levels and occupations and they have been shown in tabulated form.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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