Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Stolk, L.; ...; Barbalić, Maja; ...; Barać Lauc, Lovorka; ...; Boban, Mladen; ...; Kolčić, Ivana; ...; Martinović Klarić, Irena; ...; Polašek, Ozren; ...; Rudan, Igor; Zemunik, Tatijana; Zgaga, Lina; ...; Lunetta K.L.

doi:10.1038/ng.1051

Pregled bibliografske jedinice broj: 604179

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Stolk, L.; ...; Barbalić, Maja; ...; Barać Lauc, Lovorka; ...; Boban, Mladen; ...; Kolčić, Ivana; ... et al.

Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways // Nature genetics, 44 (2012), 260-268 doi:10.1038/ng.1051 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 604179 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways

Autori
Stolk, L. ; ... ; Barbalić, Maja ; ... ; Barać Lauc, Lovorka ; ... ; Boban, Mladen ; ... ; Kolčić, Ivana ; ... ; Martinović Klarić, Irena ; ... ; Polašek, Ozren ; ... ; Rudan, Igor ; Zemunik, Tatijana ; Zgaga, Lina ; ... ; Lunetta K.L.

Izvornik
Nature genetics (1061-4036) 44 (2012); 260-268

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
menopause; loci; genetics

Sažetak
To newly identify loci for age at natural menopause, we carried out a meta-analysis of 22 genome-wide association studies (GWAS) in 38, 968 women of European descent, with replication in up to 14, 435 women. In addition to four known loci, we identified 13 loci newly associated with age at natural menopause (at P < 5 × 10(-8)). Candidate genes located at these newly associated loci include genes implicated in DNA repair (EXO1, HELQ, UIMC1, FAM175A, FANCI, TLK1, POLG and PRIM1) and immune function (IL11, NLRP11 and PRRC2A (also known as BAT2)). Gene-set enrichment pathway analyses using the full GWAS data set identified exoDNase, NF-κB signaling and mitochondrial dysfunction as biological processes related to timing of menopause.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA

Projekti:
216-1080315-0302 - Odrednice zdravlja i bolesti u općoj i izoliranim ljudskim populacijama (Polašek, Ozren, MZOS ) ( CroRIS)

Ustanove:
Medicinski fakultet, Split

Profili:

Maja Barbalić (autor)