Naslov
Osteopontin expression is an independent factor for survival in oral squamous cell carcinoma: a computer assisted analysis on TMA sections
(Osteopontin expression is an independent factor for poor survival in oral squamous cell carcinoma: a computer assisted analysis on TMA sections)

Autori
Avirović, Manuela ; Matušan-Ilijaš, Koviljka ; Damante, Giuseppe ; Fabrro, Dora ; Cerović, Robert ; Juretić, Mirna ; Grahovac, Blaženka ; Jonjić, Nives ; Lučin, Ksenija

Izvornik
Journal of oral pathology & medicine (0904-2512) 42 (2012), 8; 620-626

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cancer; oral; osteopontin; Tissue Array Analysis

Sažetak
Ostepontin (OPN) is noncollagenous extracellular matrix protein involved in various physiological and pathological events, including tumor progression. The aim of this study was to analyze the expression of OPN in normal oral mucosa and oral squamous cell carcinoma (OSCC), and to assess its prognostic significance. The expression of OPN was immunohistochemicaly analyzed in 86 OSCC and compared to clinicopathological variable such as tumor size, nodal stage, WHO clinical stage, Ki-67 proliferation index, and patients' outcome. OPN mRNA was analyzed using quantitative real-time PCR and compared with protein OPN expression and clinical outcome in 18 OSCC samples. The expression of OPN protein was found in OSCC tumor cells (t-OPN) and various stromal cells (s-OPN). High level of t-OPN expression was associated with nodal stage (p=0, 045), WHO clinical stage (p=0, 033), and poor clinical outcome (p=0.022). In multivariate analysis OPN emerged as the independent factor for survival (p=0.049). Although correlated with t-OPN expression (p=0, 005), s-OPN expression showed only a trend for a longer survival (p=0.161). OPN is upregulated in tumor and stromal OSCC cells. Tumor cell-derived OPN is involved in tumor progression and can independently predict the clinical outcome. Stromal-derived OPN probably has different function compared to OPN secreted from tumor cells.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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