Naslov
The therapeutic effects of the combined use of American ginseng (Panax quinquefolius L.) extract and Korean red ginseng (Panax Ginseng C.A. Meyer) extract in the management of type 2 diabetes mellitus and cardiovascular risk factors

Autori
Rahelić, Dario ; Božikov, Velimir ; Jovanovski, Elena ; Jenkins, Alexandra ; Mucalo, Iva ; Romić, Željko ; Vuksan, Vladimir

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
30th International Symposium on Diabetes and Nutrition / - , 2012, 25-25

Skup
30th International Symposium on Diabetes and Nutrition

Mjesto i datum
Atena, Grčka, 28.06.2012. - 01.07.2012

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
American ginseng; Korean red ginseg; Type 2 diabetes mellitus; glycemic control; cardiovascular risk factors

Sažetak
Background: Combination therapy has proven to be an effective treatment strategy for control of diabetes and heart disease. We have previously shown that American (AG) anf Korean Reg Ginseng (KRG) improve glycemia and vascular parameters. Methods: As these two ginsengs are suggestive of complementary mechanisms of action, the study was designed to investigate their therapeutic potential when taken in combination. Hence, we evaluated the efficacy and safety of 3g/day supplementation of AG+KRG extracts in 48 well controlled (A1c=6, 5-8, 1%) Type-2 diabetes individuals. The participants were kept constant on a weight maintenance diet and/or their routine antihyperglycemic and antihypertensive medicationthroughout the course of the study. The study was a 12-week randomized, double-blind, placebo-controlled, parallel design conducted in two centres. Results: The combination therapy demonstrated a good safety profile, with HbA1c levels significantly reduced (p=0, 03) and systolic blood pressure lowered by 5 mmHg (p=0, 052) after 12 weeks of therapy compared with placebo. This study indicated that a combined treatment of AG+KRG, added to conventional treatment, may have an impact on glycemic and vascular control in diabetes with no adverse effects. Conclusions: Although preliminary, these findings encourage further investigation of the mechanism and the roles of AG, KRG and their active components. They also highlight limitations in ginseng research and the need to impose strict regulations to facilitate its physiology-compositionstandardization.

Izvorni jezik
Engleski

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