Naslov
Highly attenuated MCMV vector expressing NKG2D ligand RAE-1 gamma provides long-lived memory CD8+T cells with outstanding protective capacity

Autori
Tršan, Tihana ; Busche, Andreas ; Babić, Marina ; Tomić, Adriana ; Golemac, Mijo ; Lemmermann, Niels ; Brinkmann, Melanie ; Jäger, Wiebke ; Abram, Maja ; Krmpotić, Astrid ; Messerle, Martin ; Jonjić, Stipan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Congenital CMV Conference and the International CMV/Betaherpesvirus Workshop : Book of abstracts / - , 2012

Skup
Congenital CMV Conference and the International CMV/Betaherpesvirus Workshop

Mjesto i datum
San Francisco (CA), Sjedinjene Američke Države, 29.10.2012. - 02.11.2012

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
MCMV; NKG2D ligand RAE-1; CD8+T cells

Sažetak
There is a large number of pathogens for which post-infection acquired immunity does not fully protect against re-infection and disease. Therefore, vaccines which offer superior protection compared to the one following natural infection are needed. We have previously demonstrated that a recombinant CMV expressing a cellular ligand for the NKG2D receptor has tremendous potential for the induction of a potent antiviral immune response in spite of a strong attenuation in vivo. In this study we have used a MCMV vector expressing NKG2D ligand RAE-1gamma and the CD8+ T cell epitope of Listeria monocytogenes and have demonstrated that the expression of NKG2D ligand dramatically enhanced the effectiveness and longevity of epitope-specific CD8+ T cell response, conferring protection against a subsequent challenge infection with Listeria monocytogenes. We believe that a similar approach can be used in CD8+ T cell-based vaccination strategies against multiple human pathogens.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA