The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence.

Nikolac, Matea; Šagud, Marina; Nedić, Gordana; Nenadić Šviglin, Korona; Mihaljević Peleš, Alma; Uzun, Suzana; Vuskan Čusa, Bjanka; Kozumplik, Oliver; Živković, Maja; Mustapić, Maja; Jakovljević, Miro; Pavlović, Mladen; Muck-Šeler, Dorotea; Borovečki, Fran; Pivac, Nela

doi:10.1016/j.psychres.2012.08.001

Pregled bibliografske jedinice broj: 599485

The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence.

Nikolac, Matea; Šagud, Marina; Nedić, Gordana; Nenadić Šviglin, Korona; Mihaljević Peleš, Alma; Uzun, Suzana; Vuskan Čusa, Bjanka; Kozumplik, Oliver; Živković, Maja; Mustapić, Maja et al.

The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence. // Psychiatry research, 205 (2013), 1/2; 179-180 doi:10.1016/j.psychres.2012.08.001 (podatak o recenziji nije dostupan, pismo uredniku, znanstveni)

CROSBI ID: 599485 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
The lack of association between catechol-O-methyl-transferase Val108/158Met polymorphism and smoking in schizophrenia and alcohol dependence.

Autori
Nikolac, Matea ; Šagud, Marina ; Nedić, Gordana ; Nenadić Šviglin, Korona ; Mihaljević Peleš, Alma ; Uzun, Suzana ; Vuskan Čusa, Bjanka ; Kozumplik, Oliver ; Živković, Maja ; Mustapić, Maja ; Jakovljević, Miro ; Pavlović, Mladen ; Muck-Šeler, Dorotea ; Borovečki, Fran ; Pivac, Nela

Izvornik
Psychiatry research (0165-1781) 205 (2013), 1/2; 179-180

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pismo uredniku, znanstveni

Ključne riječi
catechol-O-methyltransferase (COMT); shizophrenia; alcohol dependence; smoking; association study

Sažetak
The study elucidated the association between the COMT Val108/158Met polymorphism and smoking in patients with schizophrenia, patients with alcohol dependence and healthy control subjects. The stepwise logistic regression (odds ratio (OR)=1.56, 95% confidence interval (CI)=1.10–2.23, P=0.014) and the χ2 test (P=0.008) revealed that the COMT Val/Val genotype was significantly associated with smoking in healthy male subjects. Although the hypothesis of the study was that COMT Val108/158Met genotypes will be significantly associated with smoking in schizophrenia and alcohol dependence, our study showed for the first time the lack of significant association between smoking and COMT Val108/158Met polymorphism in schizophrenia, and confirmed no association between smoking and COMT Val108/158Met in alcoholism.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
022-0222411-2407 - Procjena rizika pobola i smrtnosti u populaciji Hrvatske: prospektivna studija (Pavlović, Mladen, MZOS ) ( CroRIS)
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( CroRIS)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( CroRIS)
108-1080037-0323 - Multidimenzionalna analiza bioloških pokazatelja u duševnim poremećajima (Jakovljević, Miro, MZOS ) ( CroRIS)
108-1081874-1923 - Genomska analiza transkriptoma i interaktoma u bolesnika s kompleksnim bolestima (Borovečki, Fran, MZOS ) ( CroRIS)
108-1083509-3511 - Nuspojave psihofarmaka u bolesnika s psihotičnim i afektivnim poremećajima (Uzun, Suzana, MZOS ) ( CroRIS)
108-1083509-3513 - Farmakogenetska varijabilnost u psihijatrijskih bolesnika (Mihaljević-Peleš, Alma, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Klinički bolnički centar Zagreb

Profili:

Oliver Kozumplik (autor)