Naslov
Biomarkers of inflammation and angiographic score in patients with peripheral arterial disease

Autori
Perkov, S ; Flegar-Meštrić, Z ; Vidjak, V ; Novačić, K ; Slavica, M ; Kavur, L.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Biochemia Medica 2012 ; 22(3)267-402 ; A17-A204 / Šimundić, AM - Zagreb : Hrvatsko društvo za medicinsku biokemiju i laboratorijsku medicinu (HDMBLM), 2012, A68-A69

Skup
2nd European Joint Congress of European Federation of Clinical Chemistry and Laboratory Medicine (EFCC) and European Union of Medical Specialists (UEMS)/ 7th Congress of Croatian Society of Medical Biochemistry and Laboratory Medicine (CSMBLM)

Mjesto i datum
Dubrovnik, Hrvatska, 10.10.2012. - 13.10.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
biomarkers; inflammation; peripheral arterial disease

Sažetak
Background. Inflammation plays an important role in the pathophysiology of peripheral arterial disease (PAD). The aim of this study was to investigate association of C-reactive protein (CRP) concentrations and the platelet-activating factor acetylhydrolase (PAF-AH) activity, as novel biomarkers of inflammation with the angiographic score in patients with PAD. Materials and methods. The study included 110 patients with angiographically confirmed diagnosis PAD and 118 control subjects. The serum PAF-AH activity was determined by spectrophotometric assay (Azwell Inc., Auto PAF-AH, Osaka, Japan). CRP concentration was determined by high-sensitivity imunoturbidimetric assay (Beckman Coulter, OSR 6229, Ireland). The distal aorta plus 10 arteries of each lower extremity were scored on the basis of vessel lumen reduction: 1 if stenoses involved a reduction in the vessel lumen of <50%, 2 if stenoses involved 50 to 99% reduction and 3 if total occlusion was present. The sum of the points was called the angiographic score. Results. The patients had significantly higher concentrations of CRP, median (interquartile range): 3, 70 (1, 78-7, 40) vs. 1, 40 (0, 60-2, 43), p<0, 001. The serum PAF-AH activity did not differ between patients and control group 405 (330-471) vs. 406 (359-479), p=0, 591. CRP concentrations and PAF-AH activity in patients with PAD was not significantly associated with the angiographic score (r=0, 07, p= 0, 461 ; r= -0, 08, p= 0, 450, respectively). Conclusions. This study confirmed the role a low CRP concentrations as risk factors in the development of PAD, but there is no evidence that CRP concentrations or PAF-AH activity are related with the angiographic score.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

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