Pregled bibliografske jedinice broj: 597203
Increased Susceptibility to Yersinia enterocolitica Infection of Tff2 Deficient Mice
Increased Susceptibility to Yersinia enterocolitica Infection of Tff2 Deficient Mice // Cellular physiology and biochemistry, 30 (2012), 4; 853-862 doi:10.1159/000341463 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 597203 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Increased Susceptibility to Yersinia enterocolitica Infection of Tff2 Deficient Mice
Autori
Shah, Aftab Ali ; Mihalj, Martina ; Ratkay, Ivana ; Lubka-Pathak, Maria ; Balogh, Peter ; Klingel, Karin ; Bohn, Ervin ; Blin, Nikolaus ; Baus-Lončar, Mirela
Izvornik
Cellular physiology and biochemistry (1015-8987) 30
(2012), 4;
853-862
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
cytoprotective peptides ; trefoil factor family ; gastrointestinal tract ; Yersinia infections
Sažetak
TFF2 is one of the members of the trefoil factor family, known for its role in protection of gastrointestinal epithelia upon injury ; however, recent studies suggest that TFF2 could also play an important role in the immune system. In the present study Tff2 deficient and wild type mice were infected by Y. enterocolitica which resulted in a lethal outcome in all Tff2 deficient mice, but not in WT animals. Yersinia invaded Peyer's patches more efficiently as shown by high bacterial titers in the KO mice while wild type mice displayed lower titers and a visible bacterial accumulation in the intestine. Bacterial accumulation in Peyer's patches of Tff2 deficient mice was accompanied by increased recruitment of macrophages. While an increased level of MAC-1 positive cells was observed in the spleens of both Tff2 deficient and WT mice at third day post infection, bacterial dissemination to liver, lung and kidneys was observed only in Tff2 knock-out mice. Analysis of the cellular composition of spleen did not reveal any substantial alteration to WT animals, suggesting possible disregulation of hemopoietic cells involved in immune response to Y. enterocolitica. These new data indicate that Tff2 plays an important role in immune response by protecting the organism from consequences of infection and that Tff2 knock-out mice react adversely to bacterial infections, in this case specifically to Y. enterocolitica.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
219-0982914-2179 - Uloga malih zaštitinih TFF proteina u zdravlju i bolesti (Belovari, Tatjana, MZOS ) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Osijek
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
