Naslov
Interaction of cadmium with essential trace elements after oral cadmium exposure: comparing non-pregnant and pregnant rats

Autori
Sulimanec, Antonija ; Mikolić, Anja ; Jurasović, Jasna ; Piasek, Martina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book "Cadmium Symposium 2012" (ICS 2012) / - Sassari, 2012

Skup
International Cadmium Symposium 2012

Mjesto i datum
Sassari, Italija, 08.06.2012. - 09.06.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cadmium; element interaction; micronutrients; pregnancy; rats

Sažetak
Cadmium accumulates in mammalian internal organs, especially the liver, kidney, and placenta. It has strong affinity to biological structures with -SH groups, similarly to iron and zinc, which is the basis for their interaction at different stages of element biokinetics. Specific anatomical changes and increased nutritional requirements in women during childbearing age enhance gastrointestinal absorption of both micronutrients and toxic elements. The aim of our work was to evaluate and compare the effects of oral cadmium exposure on cadmium, iron and zinc distribution in non-pregnant and pregnant rats and in the foetuses. Female (Wistar) rats were exposed to 50 ppm Cd (as chloride) in demineralised water (Cd-exposed) Non-pregnant rats (N=15) were exposed for 20 days and pregnant rats (N=10) from gestation day 1 through 20. Respective controls (non-pregnant N=5 ; pregnant N=14) were supplied with demineralised water. The rats were then anaesthetised and euthanized. Whole blood was sampled from the heart and the liver, right kidney, placentas, and whole foetuses were dissected and prepared for analysis of cadmium, iron, and zinc by atomic absorption spectrometry. Cadmium exposure increased the concentration of blood, kidney, and liver cadmium whereas the concentration of liver and kidney iron decreased. These effects were significantly more pronounced in Cd-exposed pregnant than non-pregnant rats. Liver zinc increased in all rats and kidney zinc decreased only in pregnant Cd-exposed rats. Cadmium accumulation in the placentas was associated with decreases in placental zinc and foetal iron. Cadmium exposure causes more perturbations in essential microelements in tissues during pregnancy and disrupts their placental transport to the foetus. Increased cadmium and zinc retention in maternal organs and reduced foetal zinc and iron availability may compromise foetal growth and development.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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