Naslov
The comparison of the effects of cadmium exposure on trace element distribution in rats: oral versus parenteral exposure during pregnancy

Autori
Mikolić, Anja ; Sulimanec, Antonija ; Vihnanek Lazarus, Maja ; Piasek, Martina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstract Book "Cadmium Symposium 2012" (ICS 2012) / - Sassari, 2012

Skup
International Cadmium Symposium 2012

Mjesto i datum
Sassari, Italija, 08.06.2012. - 09.06.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cadmium; element distribution; foetus; iron; maternal compartments; zinc

Sažetak
Main sources of cadmium exposure in general population are food, water, and tobacco smoke. Cadmium absorption after respiratory (parenteral) exposure is on avg. 5-10 times higher than after gastrointestinal absorption. The latter increases 2-3 times during gestation in rats. Cadmium accumulates in internal organs, including the placenta, and interacts with essential elements. The aim of this investigation was to compare cadmium and essential element distribution in maternal tissues and foetuses in rats after oral vs. parenteral cadmium exposure during pregnancy. Methods In our previous investigations, we evaluated the effects of cadmium in rats parenterally exposed (by osmotic pumps sc.) from gestation day (GD) 1 through 19 at total dose 3 or 5 mg Cd/kg b.wt (BioMetals 2004, 17:1–14). In a recent investigation, female rats (Wistar) were exposed orally to 50 ppm Cd (as chloride) in demineralised water (7.26±0.86 mg Cd/kg b.wt a day) from GD 1 to 20. The rats were then anaesthetised and euthanatized. Blood was sampled from the heart. Internal organs (liver, kidney), and placentas and foetuses were dissected after exsanguination from abdominal aorta. Cadmium, zinc and iron were analysed in tissues by atomic absorption spectrometry. We found no effect of cadmium exposure on the weights of mother rats, fresh organs, and foetuses. Cadmium concentrations increased in all tissues of exposed rats. Both routes of exposure increased zinc in maternal liver and decreased it in the foetus ; only oral exposure reduced placental zinc. Oral cadmium exposure decreased iron in maternal organs and foetuses. Parenteral exposure decreased iron only in maternal organs but increased it in foetal body and the liver. Optimal zinc and iron concentrations are essential for foetal growth. Different iron perturbations in foetal compartments after oral vs. parenteral exposure indicate different cadmium-iron interaction that depends on the route of maternal exposure.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

POVEZANOST RADA