Naslov
New acyclic purine nucleoside analogues containing exocyclic pyrrolo moiety: synthetic, NMR and X-ray crystal structure studies

Autori
Raić, Silvana ; Pongračić, Mario ; Vorkapić-Furač, Jasna ; Vikić-Topić, Dražen ; Hergold-Brundić, Antonija ; Nagl, Ante ; Mintas, Mladen

Izvornik
Croatica chemica acta (0011-1643) 69 (1996), 3; 967-986

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
acyclic purine nucleoside analogues ; 1H NMR ; 13C NMR ; COSY ; NOESY ; HETCOR ; X-Ray crystallography

Sažetak
The synthesis of the novel 6-(N-pyrrolyl)purine nucleoside analogues containing acyclic side chains attached to the purine ring at N-9 is described. The structures were determined by 1H and 13C NMR on the basis of chemical shifts, substituent induced shifts, C-H coupling constants and connectivity in COSY, NOESY and HETCOR spectra. Unequivocal proof for the stereostructure of 6 was obtained by its X-ray crystallographic analysis. Geometrical data from X-ray structural analysis showed that the two 6-(N-pyrrolyl)purine rings involved in the skeleton of 6 are anti-disposed but not centrosymmetric with respect to the central aliphatic bridge.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA