Naslov
Cadmium as a placental endocrine disruptor in humans

Autori
Piasek, Martina ; Jurasović, Jasna ; Mikolić, Anja ; Stasenko, Sandra ; Kušec, Vesna ; Henson, Michael C.

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Abstracts of the 48th Congress of the European Societies of Toxicology, EUROTOX 2012 ; u: Toxicology Letters 211 (2012) (S1) / - : Elsevier, 2012, S37-S38

Skup
EUROTOX 2012, 48th Congress of the European Societies of Toxicology "Safety Science Serving Society"

Mjesto i datum
Stockholm, Švedska, 17.06.2012. - 20.06.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
cadmium; estradiol; leptin; placenta; progesterone; tobacco smoke

Sažetak
Tobacco smoke may be considered a mixture of endocrine-disrupting chemicals. It consists of numerous elements and compounds including 30 metal ions with cadmium concentration being the highest. There is emerging evidence that cadmium has potential to act as an endocrine disruptor of gonads and reproductive function in mammals, including humans. It can alter ovarian and placental steroidogenesis, ovarian cyclicity, and pregnancy maintenance. The role of inheritable developmental toxicity related to endocrine disruption is poorly understood. Trophoblast-produced leptin may regulate fetal organogenesis and development. We conducted complementary studies on cadmium-related hormone disruption in human and rodent placenta: ex vivo analyses of progesterone and estradiol in placental tissue of healthy cigarette smokers post partum whose placental cadmium concentrations were twice as high as respective levels in nonsmokers ; in vivo assessment of direct cadmium effects on progesterone and leptin production in human trophoblast cells co-cultured with CdCl2 ; assessment of placental steroidogenesis in rats after parenteral and oral cadmium exposure during gestation. We found that increased cadmium concentrations were accompanied by decreased progesterone production in both human and rodent placenta. Direct effects of cadmium on placental hormone production included specific components of the steroidogenic pathway, that is, effects on the low-density lipoprotein-cholesterol receptor and P450 side chain cleavage enzyme, as well as a dose-response decline of leptin mRNA. To conclude, cadmium has the potential to disrupt steroid and leptin production in human placenta. The sites of cadmium effects on specific components of the placental hormone biosynthetic pathway are multifaceted.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Javno zdravstvo i zdravstvena zaštita

Napomena
Presented on 19th June 2012, Oral session OS2 "Endocrine-disruptors"

POVEZANOST RADA