Naslov
Glycoprotein extract /G-90) from earthworm Eisenis foetida exerts some antioxidative activity

Autori
Grdiša, Mira ; Popović, Maja ; Hrženjak, Terezija

Izvornik
Comparative Biochemistry and Physiology Part A (1095-6433) 128 (2001), 4; 821-825

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
antioxidant; Eisenia foetida; glycolipoprotein; hydrogen peroxide; cell lines; proliferation; G-90; earthworm

Sažetak
Antioxidants protect DNA, proteins and lipids in the body from damage. These types of damages are a major contributor to aging and to degenerative diseases such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts. The effect of glycolipoprotein extract of Eisenia foetida (G-90) as an antioxidant was investigated in cultured human fibroblasts and epithelial cells. After treatment of the cells with H2O2 for 4 h, G-90 completely allows the cells to recover and stimulated their growth. When the cells were incubated with G-90 48 h before the treatment with H2O2, the oxidative damage of the cells did not occur. Thus, G-90 had an apparent protective effect against the toxicity of H2O2 and stimulated the growth of the cells. Ascorbic acid, a known antioxidant, did not allow the growth of the cells to recover after damage nor did it protect them, unless it was added simultaneously with H2O2. The antioxidative activity of G-90, together with its antibacterial and mitogen activities, could be useful in the study of G-90 as a wound healing agent.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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