Pregled bibliografske jedinice broj: 595719
Influence of coloured additives on photostability of rosuvastatin calcium
Influence of coloured additives on photostability of rosuvastatin calcium // The 9th Central European Symposium on Pharmaceutical Technology with focus on Nanopharmaceuticals and Nanomedicine
Dubrovnik, Hrvatska, 2012. (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 595719 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Influence of coloured additives on photostability of rosuvastatin calcium
Autori
Karolina Šmic, Mladen Litvić
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Skup
The 9th Central European Symposium on Pharmaceutical Technology with focus on Nanopharmaceuticals and Nanomedicine
Mjesto i datum
Dubrovnik, Hrvatska, 20.09.2012. - 22.09.2012
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
Rosuvastatin calcium; photodegradation; intramolecular cyclization; photoprotection
Sažetak
Rosuvastatin photostablity stress testing was evaluated. Photodegradation of rosuvastatin in different solvents yielded two main isomeric photoproducts. Photoproducts were isolated by means of preparative column chromatography after rosuvastatin photodegradation on preparative scale and identified by elucidation of 1D and 2D NMR spectra. Photoproducts are result of intramolecular cyclisation reaction followed by 1, 5 hydrogen shift. Solid formulations of rosuvastatin calcium with colored and uncolored additives were made and photostability was examined under long wave UV light. Photodegradation of solid rosuvastatin calcium formulations yielded much smaller amounts of photodegradation products when using coloured additives compared to noncolored additives.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Farmacija
