Naslov
EXPRESSION AND PROGNOSTIC SIGNIFICANCE OF EPIDERMAL GROWTH FACTOR RECEPTOR FAMILY IN BREAST CANCER

Autori
Ramić, Snježana ; Hiršl, Lea ; Paić, Frane ; Legčević, Zoran ; Benković, Vesna ; Knežević, Fabijan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
23rd Ljudevit Jurak International Symposium on Comparative Pathology

Mjesto i datum
Zagreb, Hrvatska, 01.06.2012. - 02.06.2012

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
EGFR; HER-2; HER-3; HER-4; Breast cancer

Sažetak
The epidermal growth factor receptor family (HER) of tyrosine kinase receptors includes HER-1, HER-2, HER-3 and HER-4 with the ability to dimerize after activation. HER-2 is over-expressed in 15%-25% of breast cancers with worse prognosis. HER-2 interaction with other receptors can influence the response of breast cancer targeted therapy. Other HER receptors are not routinely tested. We determined immunohistochemical expression of HER-1, HER-3 and HER-4 on 40 HER-2 positive and 42 HER-2 negative breast cancer biopsies. There was no statistically significant correlation of HER-1 and HER-2 ; 77.5% of HER-2 positive tumors had strong co-expression of HER-3 compared with 7.1% of HER-2 negative cases. HER-3 over-expression is correlated with poor prognostic factors such as negative estrogen and progesterone receptor and positive nodal status. HER-3 receptor was active in proliferating tumor cells with negative HER-2. HER-4 receptor showed controversial results. HER-2 negative tumors had stronger expression of HER-4 compared with HER-2 positive cases. HER-4 is associated with favorable prognostic factors such as positive estrogen receptor, low HER-2 and HER-3, but when co-expressed with HER-2 it correlates with positive nodal status. In conclusion, HER family receptors are co-expressed in breast cancer. Co-expression of HER-2 with HER-3 is associated with poor prognosis of breast cancer. Since a few tyrosine kinase inhibitors are available for breast cancer therapy, there is the need for detection of all HER receptors in breast cancer. Further analysis and methodology optimization must be considered.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA