Naslov
Porphyrins as new endogenous anti-inflammatory agents

Autori
Jelić, Dubravko ; Tatić, Iva ; Trzun, Marija ; Hrvačić, Boška ; Brajša, Karmen ; Verbanac, Donatella ; Tomašković, Marija ; Čulić, Ognjen ; Antolović, Roberto ; Glojnarić, Ines ; Weygand-Đurašević, Ivana, Vladimir-Knežević Sanda ; Mildner, Boris

Izvornik
European journal of pharmacology (0014-2999) 691 (2012), 1/3; 251-260

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
porphyrins; Fyn; TNF-α; T-lymphocyte; inflammation; cytokine

Sažetak
A series of porphyrins, tetrapyrrole natural organic compounds, are evaluated here as endogenous anti-inflammatory agents. They directly inhibit the activity of Fyn, a non-receptor Src-family tyrosine kinase, triggering anti-inflammatory events associated with down-regulation of T-cell receptor signal transduction, leading to inhibition of tumor necrosis factor alpha (TNF-α) production. This is one of the major pro-inflammatory cytokines, associated with diseases such as diabetes, tumorigenesis, rheumatoid arthritis, and inflammatory bowel disease. Porphyrins, as a chemical class, inhibited Fyn kinase activity in a non-competitive, linear-mixed fashion. In cell-based in vitro experiments on polymorphonuclear cells, porphyrins inhibited TNF-α cytokine production, T-cell proliferation, and the generation of free radicals in the oxidative burst, in a concentration-related manner. In vivo, lipopolysaccharide-induced TNF-α production in mice was inhibited by several of the porphyrins. These findings may be very important for the overall understanding of the role(s) of porphyrins in inflammation and their possible application as new anti-inflammatory agents.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Temeljne medicinske znanosti, Farmacija

POVEZANOST RADA