Naslov
3-O-Acyl Derivatives of Bridged-15-Membered Azalides : Synthesis, Structural Determination and Antibacterial Activity

Autori
Berdik-Fajdetić, Andreja ; Kobrehel, Gabrijela ; Lazarevski, Gorjana ; Štimac, Vlado ; Mutak, Stjepan

Izvornik
Croatica chemica acta (0011-1643) 78 (2005), 2; 301-312

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
azalides; synthesis; acylation; NMR spectroscopy

Sažetak
The synthesis, structural determination and biological evaluation of 15-membered azalides acylated at the C-3 position are described. 3- Descladinosyl-9a, l1-cyclic carbamate of the 9a- aza- 9a-homoerythromycin A and their 12-O-alkyl derivatives were synthesized via acidic hydrolysis of adequate 3-cladinosyl analogues. Protections of 2'-hydroxyl group were performed to furnish starting compounds for acylation of the C-3- hydroxyl group. After deprotection various 3-O- acyl derivatives were obtained and their structures confirmed by spectroscopic methods (IR, MS, NMR). The new compounds were evaluated in vitro against a panel of Gram-positive and Gram- negative bacteria and their activities compared with those of parent derivatives. The 3-O-acyl derivatives exhibited improved antibacterial activity, but it was lower than by standard macrolides.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA