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Pregled bibliografske jedinice broj: 588604

Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit

Matanović-Škugor, Maja; Štimac, Vlado; Palej, Ivana; Lugarić, Đurđica; Čipčić Paljetak, Hana; Filić, Darko; Modrić, Marina; Đilović, Ivica; Gembarovski, Dubravka; Mutak, Stjepan et al.
Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit // Bioorganic & medicinal chemistry, 18 (2010), 17; 6547-6558 doi:10.1016/j.bmc.2010.06.050 (međunarodna recenzija, članak, znanstveni)

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Naslov
Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit

Autori
Matanović-Škugor, Maja ; Štimac, Vlado ; Palej, Ivana ; Lugarić, Đurđica ; Čipčić Paljetak, Hana ; Filić, Darko ; Modrić, Marina ; Đilović, Ivica ; Gembarovski, Dubravka ; Mutak, Stjepan ; Eraković Haber, Vesna ; Holmes, David J. ; Ivezić-Schoenfeldd, Zrinka ; Alihodžić, Sulejman

Izvornik
Bioorganic & medicinal chemistry (0968-0896) 18 (2010), 17; 6547-6558

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
macrolide ; quinolone ; antibacterial activity ; resistance

Sažetak
The synthesis and antimicrobial activity of a new class of macrolide antibiotics which consist of a macrolide scaffold and a quionolone unit covalently connected by an appropriate linker are described. Optimization of several synthetic steps and structural properties of lead compound 26 are discussed. Promising antibacterial properties of this compound and some of its analogues are reported.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Ustanove:
Pliva-Istraživački institut,
Prirodoslovno-matematički fakultet, Zagreb,
Fidelta d.o.o.

Profili:

Avatar Url Dubravka Gembarovski (autor)

Avatar Url Hana Čipčić Paljetak (autor)

Avatar Url Marina Modrić (autor)

Avatar Url Darko Filić (autor)

Avatar Url Maja Matanović Škugor (autor)

Avatar Url Vesna Eraković Haber (autor)

Avatar Url Sulejman Alihodžić (autor)

Avatar Url Vlado Štimac (autor)

Avatar Url Stjepan Mutak (autor)

Avatar Url Zrinka Ivezić (autor)

Avatar Url Ivica Đilović (autor)

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com ac.els-cdn.com dx.doi.org

Citiraj ovu publikaciju:

Matanović-Škugor, Maja; Štimac, Vlado; Palej, Ivana; Lugarić, Đurđica; Čipčić Paljetak, Hana; Filić, Darko; Modrić, Marina; Đilović, Ivica; Gembarovski, Dubravka; Mutak, Stjepan et al.
Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit // Bioorganic & medicinal chemistry, 18 (2010), 17; 6547-6558 doi:10.1016/j.bmc.2010.06.050 (međunarodna recenzija, članak, znanstveni)
Matanović-Škugor, M., Štimac, V., Palej, I., Lugarić, Đ., Čipčić Paljetak, H., Filić, D., Modrić, M., Đilović, I., Gembarovski, D. & Mutak, S. (2010) Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit. Bioorganic & medicinal chemistry, 18 (17), 6547-6558 doi:10.1016/j.bmc.2010.06.050.
@article{article, author = {Matanovi\'{c}-\v{S}kugor, Maja and \v{S}timac, Vlado and Palej, Ivana and Lugari\'{c}, \DJur\djica and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Fili\'{c}, Darko and Modri\'{c}, Marina and \DJilovi\'{c}, Ivica and Gembarovski, Dubravka and Mutak, Stjepan and Erakovi\'{c} Haber, Vesna and Holmes, David J. and Ivezi\'{c}-Schoenfeldd, Zrinka and Alihod\v{z}i\'{c}, Sulejman}, year = {2010}, pages = {6547-6558}, DOI = {10.1016/j.bmc.2010.06.050}, keywords = {macrolide, quinolone, antibacterial activity, resistance}, journal = {Bioorganic and medicinal chemistry}, doi = {10.1016/j.bmc.2010.06.050}, volume = {18}, number = {17}, issn = {0968-0896}, title = {Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit}, keyword = {macrolide, quinolone, antibacterial activity, resistance} }
@article{article, author = {Matanovi\'{c}-\v{S}kugor, Maja and \v{S}timac, Vlado and Palej, Ivana and Lugari\'{c}, \DJur\djica and \v{C}ip\v{c}i\'{c} Paljetak, Hana and Fili\'{c}, Darko and Modri\'{c}, Marina and \DJilovi\'{c}, Ivica and Gembarovski, Dubravka and Mutak, Stjepan and Erakovi\'{c} Haber, Vesna and Holmes, David J. and Ivezi\'{c}-Schoenfeldd, Zrinka and Alihod\v{z}i\'{c}, Sulejman}, year = {2010}, pages = {6547-6558}, DOI = {10.1016/j.bmc.2010.06.050}, keywords = {macrolide, quinolone, antibacterial activity, resistance}, journal = {Bioorganic and medicinal chemistry}, doi = {10.1016/j.bmc.2010.06.050}, volume = {18}, number = {17}, issn = {0968-0896}, title = {Synthesis and biological activity of 4''-O-Acyl Derivatives of 14- and 15-membered Macrolides Linked to omega-Quinolone-carboxylic Unit}, keyword = {macrolide, quinolone, antibacterial activity, resistance} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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