Naslov
Photocatalytic degradation of sulfa drugs

Autori
Mirta Zrnčić, Sandra Babić, Davor Ljubas, Lidija Ćurković, Marija Kaštelan-Macan

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
13th International Chromatography School / Bolanča, Tomislav ; Ukić, Šime - Zagreb, 2012

Skup
13th International Chromatography School

Mjesto i datum
Zagreb, Hrvatska, 18.06.2012. - 19.06.2012

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
photocatalytic degradation; sulfa drugs; HPLC; mass spectrometry

Sažetak
Pharmaceuticals are chemical substances which are used to treat and prevent disease in human and in animals. In farming they are also used as additives to feedstock in order to promote growth in animals. The presence of pharmaceuticals in the environment raises a big concern due to their continuous input in the environment via different pathways. They pose a toxicological risk to different non-target organisms and in that sense they can lead to development of antibiotic resistant strains of bacteria [1, 2]. Sulfonamides are widely used because of their low cost and relative efficiency against many common bacterial infections. They are highly soluble in water and due to that they are present in different aquatic systems which has been confirmed in many researches [3]. Advanced oxidation processes have been effective in the degradation of organic pollutants and accordingly they can be applied for removal of antibiotics during the waste water treatment. In this work sulfamethazine was chosen as the representative of the group of sulfonamides. Aqueous solution of sulfamethazine was photolytically and photocatalytically degraded by UV light with different predominant wavelengths (254 and 365 nm) and by nanostructured sol – gel TiO2 film. As a photoreactor a borosilicate glass tube with immobilized TiO2 film was used. HPLC-ESI(+)-MS Agilent 1200 was used to monitor degradation of sulfamethazine and the appearance of degradation products. For chromatographic analysis polar embedded C18 Synergy Fusion column (4 μm, 150 x 2.0 mm, Phenomenex) was used. The analysis was performed using 0.1% formic acid in water and 0.1% formic acid in acetonitrile in gradient elution mode. Structural formulas of the degradation products were also proposed based on spectral analysis obtained on mass spectrometer.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Strojarstvo, Temeljne tehničke znanosti

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