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Pregled bibliografske jedinice broj: 587548

MOLECULAR INSIGHT INTO AMINOGLYCOSIDE RESISTANCE BY RIBOSOMAL RNA METHYLTRANSFERASES


Maravić Vlahoviček, Gordana
MOLECULAR INSIGHT INTO AMINOGLYCOSIDE RESISTANCE BY RIBOSOMAL RNA METHYLTRANSFERASES // FEBS3+ Meeting: From molecules to life and back Book of Abstracts / Dumić, Jerka ; Kovarik, Zrinka ; Varljen, Jadranka (ur.).
Rijeka: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2012. str. 63-63 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)


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Naslov
MOLECULAR INSIGHT INTO AMINOGLYCOSIDE RESISTANCE BY RIBOSOMAL RNA METHYLTRANSFERASES

Autori
Maravić Vlahoviček, Gordana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
FEBS3+ Meeting: From molecules to life and back Book of Abstracts / Dumić, Jerka ; Kovarik, Zrinka ; Varljen, Jadranka - Rijeka : Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2012, 63-63

ISBN
978-953-95551-4-4

Skup
FEBS3+ Meeting: From molecules to life and back

Mjesto i datum
Opatija, Hrvatska, 13.06.2012. - 16.06.2012

Vrsta sudjelovanja
Pozvano predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
ribosomal antibiotics; microbial resistance; rRNA methyltransferases

Sažetak
Overwhelming problem of bacterial resistance to antibiotics is constantly increasing by emergence and spreading of both existent and novel resistance determinants. Mechanisms of resistance that until recently were observed exclusively among bacteria that produce aminoglycoside antibiotics are now being detected in a growing number of clinical strains. There are two families of enzymes that are responsible for the high level aminoglycoside resistance in pathogenic bacteria, Arm and Kam. Both types of enzymes introduce an additional methyl group onto a specific nucleotide within the aminoglycoside binding site in the 16S rRNA within the small ribosomal subunit, thus preventing the antibiotic binding. Arm enzymes methylate G1405 and the substrate of Kam enzymes is A1408, both of which are positioned in the decoding centre of the ribosome. The structure-function relationships of the methylation mechanism will be discussed in light of the recent results on the interference with the endogenous enzyme RsmF involved in ribosomal maturation and on the biological cost of this interplay. Obtained knowledge offers new directions in design of specific molecules that would serve as a defence against aminoglycoside resistant bacteria.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Farmacija



POVEZANOST RADA


Projekti:
006-0982913-1219 - Molekularne osnove djelovanja antibiotika i mehanizmi bakterijske rezistencije (Maravić Vlahoviček, Gordana, MZOS ) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb


Citiraj ovu publikaciju:

Maravić Vlahoviček, Gordana
MOLECULAR INSIGHT INTO AMINOGLYCOSIDE RESISTANCE BY RIBOSOMAL RNA METHYLTRANSFERASES // FEBS3+ Meeting: From molecules to life and back Book of Abstracts / Dumić, Jerka ; Kovarik, Zrinka ; Varljen, Jadranka (ur.).
Rijeka: Hrvatsko društvo za biokemiju i molekularnu biologiju (HDBMB), 2012. str. 63-63 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
Maravić Vlahoviček, G. (2012) MOLECULAR INSIGHT INTO AMINOGLYCOSIDE RESISTANCE BY RIBOSOMAL RNA METHYLTRANSFERASES. U: Dumić, J., Kovarik, Z. & Varljen, J. (ur.)FEBS3+ Meeting: From molecules to life and back Book of Abstracts.
@article{article, author = {Maravi\'{c} Vlahovi\v{c}ek, Gordana}, year = {2012}, pages = {63-63}, keywords = {ribosomal antibiotics, microbial resistance, rRNA methyltransferases}, isbn = {978-953-95551-4-4}, title = {MOLECULAR INSIGHT INTO AMINOGLYCOSIDE RESISTANCE BY RIBOSOMAL RNA METHYLTRANSFERASES}, keyword = {ribosomal antibiotics, microbial resistance, rRNA methyltransferases}, publisher = {Hrvatsko dru\v{s}tvo za biokemiju i molekularnu biologiju (HDBMB)}, publisherplace = {Opatija, Hrvatska} }
@article{article, author = {Maravi\'{c} Vlahovi\v{c}ek, Gordana}, year = {2012}, pages = {63-63}, keywords = {ribosomal antibiotics, microbial resistance, rRNA methyltransferases}, isbn = {978-953-95551-4-4}, title = {MOLECULAR INSIGHT INTO AMINOGLYCOSIDE RESISTANCE BY RIBOSOMAL RNA METHYLTRANSFERASES}, keyword = {ribosomal antibiotics, microbial resistance, rRNA methyltransferases}, publisher = {Hrvatsko dru\v{s}tvo za biokemiju i molekularnu biologiju (HDBMB)}, publisherplace = {Opatija, Hrvatska} }




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