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Pregled bibliografske jedinice broj: 584485

Probing the Interactions of Macrolide Antibiotics with Membrane- Mimetics by NMR Spectroscopy

Kosol, Simone; Schrank, Evelyne; Bukvić Krajačić, Mirjana; Wagner, Gabriel E.; Meyer, Helge N.; Göbl, Christoph; Rechberger, Gerald N.; Zangger, Klaus; Novak, Predrag
Probing the Interactions of Macrolide Antibiotics with Membrane- Mimetics by NMR Spectroscopy // Journal of medicinal chemistry, 55 (2012), 11; 5632-5636 doi:10.1021/jm300647f (međunarodna recenzija, članak, znanstveni)

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Naslov
Probing the Interactions of Macrolide Antibiotics with Membrane- Mimetics by NMR Spectroscopy

Autori
Kosol, Simone ; Schrank, Evelyne ; Bukvić Krajačić, Mirjana ; Wagner, Gabriel E. ; Meyer, Helge N. ; Göbl, Christoph ; Rechberger, Gerald N. ; Zangger, Klaus ; Novak, Predrag

Izvornik
Journal of medicinal chemistry (0022-2623) 55 (2012), 11; 5632-5636

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
macrolide antibiotics; NMR; membrane mimetics; PRE

Sažetak
Interactions of macrolide antibiotics with biological membranes contribute to their bioavailability but are also involved in the formation of phospholipidosis, which is caused by the inhibition of phospholipase A1 activity. We determined the interaction strength and localization of macrolide antibiotics with membrane-mimetics. Macrolides bind to membrane-mimetics with the positively charged amino groups being close to the micelle surface and thereby protect the lipids from being degraded by phospholipase A1 rather than inhibiting the enzyme.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA

Projekti:
119-1191342-1083 - Interakcije i dizajn bioaktivnih molekula (Novak, Predrag, MZOS ) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb

Profili:

Avatar Url Predrag Novak (autor)

Poveznice na cjeloviti tekst rada:

doi pubs.acs.org

Citiraj ovu publikaciju:

Kosol, Simone; Schrank, Evelyne; Bukvić Krajačić, Mirjana; Wagner, Gabriel E.; Meyer, Helge N.; Göbl, Christoph; Rechberger, Gerald N.; Zangger, Klaus; Novak, Predrag
Probing the Interactions of Macrolide Antibiotics with Membrane- Mimetics by NMR Spectroscopy // Journal of medicinal chemistry, 55 (2012), 11; 5632-5636 doi:10.1021/jm300647f (međunarodna recenzija, članak, znanstveni)
Kosol, S., Schrank, E., Bukvić Krajačić, M., Wagner, G., Meyer, H., Göbl, C., Rechberger, G., Zangger, K. & Novak, P. (2012) Probing the Interactions of Macrolide Antibiotics with Membrane- Mimetics by NMR Spectroscopy. Journal of medicinal chemistry, 55 (11), 5632-5636 doi:10.1021/jm300647f.
@article{article, author = {Kosol, Simone and Schrank, Evelyne and Bukvic\' Kraja\v{c}ic\', Mirjana and Wagner, Gabriel E. and Meyer, Helge N. and Go\"bl, Christoph and Rechberger, Gerald N. and Zangger, Klaus and Novak, Predrag}, year = {2012}, pages = {5632-5636}, DOI = {10.1021/jm300647f}, keywords = {macrolide antibiotics, NMR, membrane mimetics, PRE}, journal = {Journal of medicinal chemistry}, doi = {10.1021/jm300647f}, volume = {55}, number = {11}, issn = {0022-2623}, title = {Probing the Interactions of Macrolide Antibiotics with Membrane- Mimetics by NMR Spectroscopy}, keyword = {macrolide antibiotics, NMR, membrane mimetics, PRE} }
@article{article, author = {Kosol, Simone and Schrank, Evelyne and Bukvic\' Kraja\v{c}ic\', Mirjana and Wagner, Gabriel E. and Meyer, Helge N. and Go\"bl, Christoph and Rechberger, Gerald N. and Zangger, Klaus and Novak, Predrag}, year = {2012}, pages = {5632-5636}, DOI = {10.1021/jm300647f}, keywords = {macrolide antibiotics, NMR, membrane mimetics, PRE}, journal = {Journal of medicinal chemistry}, doi = {10.1021/jm300647f}, volume = {55}, number = {11}, issn = {0022-2623}, title = {Probing the Interactions of Macrolide Antibiotics with Membrane- Mimetics by NMR Spectroscopy}, keyword = {macrolide antibiotics, NMR, membrane mimetics, PRE} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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