Pregled bibliografske jedinice broj: 584312
Hydroxyquinoline based binders: Promising ligands for chelatotherapy?
Hydroxyquinoline based binders: Promising ligands for chelatotherapy? // Journal of inorganic biochemistry, 105 (2011), 3; 490-496 doi:10.1016/j.jinorgbio.2010.08.014, (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 584312 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Hydroxyquinoline based binders: Promising ligands for chelatotherapy?
Autori
Budimir, Ana ; Humbert, Nicholas ; Elhabiri, Mourad ; Osinska, Iwona ; Biruš, Mladen ; Albrecht-Gary, Anne-Marie
Izvornik
Journal of inorganic biochemistry (0162-0134) 105
(2011), 3;
490-496
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Clioquinol; Alzheimer's disease; Metal ions; Stability constants
Sažetak
We report here a thorough physico-chemical study of the coordination properties of clioquinol, an oxine-type active neurological drug in Alzheimer's disease, toward biologically relevant divalent metal ions (Cu, Zn, Ni, Co and Mn). Using a fruitful combination of electrospray mass spectrometry, absorption spectrophotometry and potentiometry, we have characterized the mono- and bis-chelated metal ion species. The determination of the stability constants showed a classical thermodynamic behavior along the studied series with the cupric complexes being by far the most stable species. Our data are discussed within the scope of Alzheimer's disease.
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
006-0061247-0009 - Kinetika i mehanizam katalitičkog antioksidacijskog djelovanja Mn-porfirina (Budimir, Ana, MZOS ) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE
