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Pregled bibliografske jedinice broj: 579505

Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney


Domitrović, Robert; Cvijanović, Olga; Pernjak Pugel, Ester; Blagojević Zagorac, Gordana; Mahmutefendić, Hana; Škoda, Marko
Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney // Toxicology, 310 (2013), 115-123 doi:10.1016/j.tox.2013.05.015 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 579505 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney

Autori
Domitrović, Robert ; Cvijanović, Olga ; Pernjak Pugel, Ester ; Blagojević Zagorac, Gordana ; Mahmutefendić, Hana ; Škoda, Marko

Izvornik
Toxicology (0300-483X) 310 (2013); 115-123

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
cisplatin nephrotoxicity; luteolin; oxidative/nitrosative stress; inflammation; apoptosis

Sažetak
The aim of this study was to investigate the effects of flavone luteolin against cisplatin (CP)-induced kidney injury in mice. Luteolin at doses of 10mg/kg was administered intraperitoneally (ip) once daily for 3 days following single CP (10 or 20mg/kg) ip injection. Mice were sacrificed 24h after the last dose of luteolin. The CP treatment significantly increased serum creatinine and blood urea nitrogen and induced pathohistological changes in the kidneys. Renal oxidative/nitrosative stress was evidenced by decreased glutathione (GSH) levels and increased 3-nitrotyrosine (3-NT) and 4- hydroxynonenal (4-HNE) formation as well as cytochrome P450 2E1 (CYP2E1) expression. The CP administration triggered inflammatory response in mice kidneys through activation of nuclear factor- kappaB (NF-κB) and overexpression of tumor necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2). Simultaneously, the increase in renal p53 and caspase-3 expression indicated apoptosis of tubular cells. The administration of luteolin significantly reduced histological and biochemical changes induced by CP, decreased platinum (Pt) levels and suppressed oxidative/nitrosative stress, inflammation and apoptosis in the kidneys. These results suggest that luteolin is an effective nephroprotective agent, with potential to reduce Pt accumulation in the kidneys and ameliorate CP-induced nephrotoxicity.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija



POVEZANOST RADA


Projekti:
062-0000000-3554 - Aktivni sastojci ljekovitog bilja u terapiji fibroze jetre (Domitrović, Robert, MZOS ) ( CroRIS)
062-0621261-1269 - Perinatalni citomegalovirusni encefalitis (Pernjak-Pugel, Ester, MZOS ) ( CroRIS)
Sveučilište u Rijeci
potpora 13.06.1.2.24

Ustanove:
Medicinski fakultet, Rijeka

Poveznice na cjeloviti tekst rada:

doi ac.els-cdn.com www.sciencedirect.com

Citiraj ovu publikaciju:

Domitrović, Robert; Cvijanović, Olga; Pernjak Pugel, Ester; Blagojević Zagorac, Gordana; Mahmutefendić, Hana; Škoda, Marko
Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney // Toxicology, 310 (2013), 115-123 doi:10.1016/j.tox.2013.05.015 (međunarodna recenzija, članak, znanstveni)
Domitrović, R., Cvijanović, O., Pernjak Pugel, E., Blagojević Zagorac, G., Mahmutefendić, H. & Škoda, M. (2013) Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney. Toxicology, 310, 115-123 doi:10.1016/j.tox.2013.05.015.
@article{article, author = {Domitrovi\'{c}, Robert and Cvijanovi\'{c}, Olga and Pernjak Pugel, Ester and Blagojevi\'{c} Zagorac, Gordana and Mahmutefendi\'{c}, Hana and \v{S}koda, Marko}, year = {2013}, pages = {115-123}, DOI = {10.1016/j.tox.2013.05.015}, keywords = {cisplatin nephrotoxicity, luteolin, oxidative/nitrosative stress, inflammation, apoptosis}, journal = {Toxicology}, doi = {10.1016/j.tox.2013.05.015}, volume = {310}, issn = {0300-483X}, title = {Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney}, keyword = {cisplatin nephrotoxicity, luteolin, oxidative/nitrosative stress, inflammation, apoptosis} }
@article{article, author = {Domitrovi\'{c}, Robert and Cvijanovi\'{c}, Olga and Pernjak Pugel, Ester and Blagojevi\'{c} Zagorac, Gordana and Mahmutefendi\'{c}, Hana and \v{S}koda, Marko}, year = {2013}, pages = {115-123}, DOI = {10.1016/j.tox.2013.05.015}, keywords = {cisplatin nephrotoxicity, luteolin, oxidative/nitrosative stress, inflammation, apoptosis}, journal = {Toxicology}, doi = {10.1016/j.tox.2013.05.015}, volume = {310}, issn = {0300-483X}, title = {Luteolin ameliorates cisplatin-induced nephrotoxicity in mice through inhibition of platinum accumulation, inflammation and apoptosis in the kidney}, keyword = {cisplatin nephrotoxicity, luteolin, oxidative/nitrosative stress, inflammation, apoptosis} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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