Alzheimer's disease and type 2 diabetes: The association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes

Mustapić, Maja; Popović-Hadžija, Marijana; Pavlović, Mladen; Pavković, Pajica; Presečki, Paola; Mrazovac, Danijela; Mimica, Ninoslav; Korolija, Marina; Pivac, Nela; Muck-Šeler, Dorotea

doi:10.1007/s11011-012-9310-1

Pregled bibliografske jedinice broj: 578019

Alzheimer's disease and type 2 diabetes: The association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes

Mustapić, Maja; Popović-Hadžija, Marijana; Pavlović, Mladen; Pavković, Pajica; Presečki, Paola; Mrazovac, Danijela; Mimica, Ninoslav; Korolija, Marina; Pivac, Nela; Muck-Šeler, Dorotea

Alzheimer's disease and type 2 diabetes: The association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes // Metabolic brain disease, 27 (2012), 4; 507-512 doi:10.1007/s11011-012-9310-1 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 578019 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Alzheimer's disease and type 2 diabetes: The association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes

Autori
Mustapić, Maja ; Popović-Hadžija, Marijana ; Pavlović, Mladen ; Pavković, Pajica ; Presečki, Paola ; Mrazovac, Danijela ; Mimica, Ninoslav ; Korolija, Marina ; Pivac, Nela ; Muck-Šeler, Dorotea

Izvornik
Metabolic brain disease (0885-7490) 27 (2012), 4; 507-512

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alzheimer’s disease; apolipoprotein E; diabetes type 2; gene; polymorphism; tumor necrosis factor- alpha

Sažetak
Type 2 diabetes (T2D) and Alzheimer’s disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-α) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjects with T2D. The aim was to determine ApoE and G-308A TNF-α gene polymorphisms in unrelated Croatian Caucasians: 207 patients with sporadic AD, 196 T2D patients and 456 healthy controls. Patients with AD had higher frequency of ApoE4 allele compared to T2D patients and controls. The significant association, observed between ApoE2 allele and T2D, disappeared after the data were adjusted for age and sex. The genotype or allele frequencies of G-308A TNF-α gene polymorphism were similar among the patients with AD, T2D and healthy controls. In conclusion, these results do not support the hypothesis that the A allele of G-308A TNF-α gene polymorphism is associated either with AD or T2D. Our data confirm the association between the ApoE4 allele and AD, and point out the E2 allele of ApoE gene as the possible risk factor for T2D.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA

Projekti:
022-0222411-2407 - Procjena rizika pobola i smrtnosti u populaciji Hrvatske: prospektivna studija (Pavlović, Mladen, MZOS ) ( CroRIS)
098-0982464-2460 - Dobivanje struktura nalik Langerhansovim otočićima iz matičnih stanica miša (Hadžija, Mirko, MZOS ) ( CroRIS)
098-0982522-2455 - Molekularna podloga i liječenje psihijatrijskih i stresom izazvanih poremećaja (Pivac, Nela, MZOS ) ( CroRIS)
098-0982522-2457 - Farmakogenomika i proteomika serotoninskog i kateholaminskog sustava (Muck-Šeler, Dorotea, MZOS ) ( CroRIS)
COST Action CM1103.
108-1081870-2418 - BAP, shizoafektivni poremećaj,shizofrenija:Različite bolesti ili kontinuum? (Folnegović-Šmalc, Vera, MZOS ) ( CroRIS)

Ustanove:
Institut za medicinska istraživanja i medicinu rada, Zagreb,
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Psihijatrijska bolnica "Sveti Ivan" Zagreb

Profili:

Dorotea Muck-Šeler (autor)